Expression and Regulation of the Leukemia Inhibitory Factor/D Factor Gene in Human T-Cell Leukemia Virus Type 1 Infected T-Cell Lines

Tomoyo Umemiya-Okada; Toshiki Natazuka; Toshimitsu Matsui; Mitsuhiro Ito; Taizo Taniguchi; Yoshinobu Nakao

Expression and Regulation of the Leukemia Inhibitory Factor/D Factor Gene in Human T-Cell Leukemia Virus Type 1 Infected T-Cell Lines

Tomoyo Umemiya-Okada
, Toshiki Natazuka
, Toshimitsu Matsui
, Mitsuhiro Ito
, Taizo Taniguchi
, Yoshinobu Nakao

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The expression of the leukemia inhibitory factor/D factor (LIF) gene in human T-cell leukemia virus type 1 infected T-cell lines was examined. Human T-cell leukemia virus type 1 infected T-cell lines MT-1, MT-2, H89-59, H89-79, and H109 expressed LIF mRNA, but the T-cell lines MOLT-4 and TALL-1 did not. LIF mRNA expression was enhanced by interleukin 2 or 12-0-tetradecanoylphorbol-13-acetate in MT-2 cells. The biological activity of LIF was detected in culture medium enhanced by interleukin 2 in MT-2 cells. The expression of LIF mRNA was suppressed by la,25-dihydroxyvitamin D3 and dexameth-asone. These results imply that the expression of the LIF gene is involved in the development of hypercalcemia and abnormalities of the immune system observed in patients with adult T-cell leukemia.

Original language	English
Pages (from-to)	6961-6965
Number of pages	5
Journal	Cancer Research
Volume	52
Issue number	24
State	Published - Dec 1992
Externally published	Yes

Cite this

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title = "Expression and Regulation of the Leukemia Inhibitory Factor/D Factor Gene in Human T-Cell Leukemia Virus Type 1 Infected T-Cell Lines",

abstract = "The expression of the leukemia inhibitory factor/D factor (LIF) gene in human T-cell leukemia virus type 1 infected T-cell lines was examined. Human T-cell leukemia virus type 1 infected T-cell lines MT-1, MT-2, H89-59, H89-79, and H109 expressed LIF mRNA, but the T-cell lines MOLT-4 and TALL-1 did not. LIF mRNA expression was enhanced by interleukin 2 or 12-0-tetradecanoylphorbol-13-acetate in MT-2 cells. The biological activity of LIF was detected in culture medium enhanced by interleukin 2 in MT-2 cells. The expression of LIF mRNA was suppressed by la,25-dihydroxyvitamin D3 and dexameth-asone. These results imply that the expression of the LIF gene is involved in the development of hypercalcemia and abnormalities of the immune system observed in patients with adult T-cell leukemia.",

author = "Tomoyo Umemiya-Okada and Toshiki Natazuka and Toshimitsu Matsui and Mitsuhiro Ito and Taizo Taniguchi and Yoshinobu Nakao",

year = "1992",

month = dec,

language = "English",

volume = "52",

pages = "6961--6965",

journal = "Cancer Research",

issn = "0008-5472",

publisher = "American Association for Cancer Research Inc.",

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TY - JOUR

T1 - Expression and Regulation of the Leukemia Inhibitory Factor/D Factor Gene in Human T-Cell Leukemia Virus Type 1 Infected T-Cell Lines

AU - Umemiya-Okada, Tomoyo

AU - Natazuka, Toshiki

AU - Matsui, Toshimitsu

AU - Ito, Mitsuhiro

AU - Taniguchi, Taizo

AU - Nakao, Yoshinobu

PY - 1992/12

Y1 - 1992/12

N2 - The expression of the leukemia inhibitory factor/D factor (LIF) gene in human T-cell leukemia virus type 1 infected T-cell lines was examined. Human T-cell leukemia virus type 1 infected T-cell lines MT-1, MT-2, H89-59, H89-79, and H109 expressed LIF mRNA, but the T-cell lines MOLT-4 and TALL-1 did not. LIF mRNA expression was enhanced by interleukin 2 or 12-0-tetradecanoylphorbol-13-acetate in MT-2 cells. The biological activity of LIF was detected in culture medium enhanced by interleukin 2 in MT-2 cells. The expression of LIF mRNA was suppressed by la,25-dihydroxyvitamin D3 and dexameth-asone. These results imply that the expression of the LIF gene is involved in the development of hypercalcemia and abnormalities of the immune system observed in patients with adult T-cell leukemia.

AB - The expression of the leukemia inhibitory factor/D factor (LIF) gene in human T-cell leukemia virus type 1 infected T-cell lines was examined. Human T-cell leukemia virus type 1 infected T-cell lines MT-1, MT-2, H89-59, H89-79, and H109 expressed LIF mRNA, but the T-cell lines MOLT-4 and TALL-1 did not. LIF mRNA expression was enhanced by interleukin 2 or 12-0-tetradecanoylphorbol-13-acetate in MT-2 cells. The biological activity of LIF was detected in culture medium enhanced by interleukin 2 in MT-2 cells. The expression of LIF mRNA was suppressed by la,25-dihydroxyvitamin D3 and dexameth-asone. These results imply that the expression of the LIF gene is involved in the development of hypercalcemia and abnormalities of the immune system observed in patients with adult T-cell leukemia.

UR - https://www.scopus.com/pages/publications/0027085805

M3 - Article

C2 - 1458488

AN - SCOPUS:0027085805

SN - 0008-5472

VL - 52

SP - 6961

EP - 6965

JO - Cancer Research

JF - Cancer Research

IS - 24

ER -

Expression and Regulation of the Leukemia Inhibitory Factor/D Factor Gene in Human T-Cell Leukemia Virus Type 1 Infected T-Cell Lines

Abstract

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