Expression and Regulation of the Leukemia Inhibitory Factor/D Factor Gene in Human T-Cell Leukemia Virus Type 1 Infected T-Cell Lines

Tomoyo Umemiya-Okada, Toshiki Natazuka, Toshimitsu Matsui, Mitsuhiro Ito, Taizo Taniguchi, Yoshinobu Nakao

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7 Scopus citations

Abstract

The expression of the leukemia inhibitory factor/D factor (LIF) gene in human T-cell leukemia virus type 1 infected T-cell lines was examined. Human T-cell leukemia virus type 1 infected T-cell lines MT-1, MT-2, H89-59, H89-79, and H109 expressed LIF mRNA, but the T-cell lines MOLT-4 and TALL-1 did not. LIF mRNA expression was enhanced by interleukin 2 or 12-0-tetradecanoylphorbol-13-acetate in MT-2 cells. The biological activity of LIF was detected in culture medium enhanced by interleukin 2 in MT-2 cells. The expression of LIF mRNA was suppressed by la,25-dihydroxyvitamin D3 and dexameth-asone. These results imply that the expression of the LIF gene is involved in the development of hypercalcemia and abnormalities of the immune system observed in patients with adult T-cell leukemia.

Original languageEnglish
Pages (from-to)6961-6965
Number of pages5
JournalCancer Research
Volume52
Issue number24
StatePublished - Dec 1992
Externally publishedYes

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