Exploring the relationship between essential tremor and Parkinson's disease

Joohi Shahed, Joseph Jankovic

Research output: Contribution to journalReview articlepeer-review

182 Scopus citations

Abstract

Although essential tremor (ET) and Parkinson's disease (PD) are considered distinct disorders, there is overlap in some clinical features. In some PD patients, a long-standing postural tremor in the hands may precede the onset of parkinsonian features by several years or decades. Furthermore, large families with both ET and PD phenotypes have been described and autopsy studies have demonstrated Lewy body pathology in brains of ET patients. Functional neuroimaging suggests that some ET patients have dopaminergic deficit. We examine here the evidence for and against an association between ET and PD, and critically review data supporting the notion that a subset of ET patients is predisposed to developing PD.

Original languageEnglish
Pages (from-to)67-76
Number of pages10
JournalParkinsonism and Related Disorders
Volume13
Issue number2
DOIs
StatePublished - Mar 2007
Externally publishedYes

Keywords

  • Clinical features
  • Epidemiology
  • Essential tremor
  • Functional neuroimaging
  • Genetics
  • Parkinson's disease
  • Pathology
  • Treatment
  • Tremor-dominant Parkinson's disease

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