TY - JOUR
T1 - Exploring new kingdoms
T2 - The role of extracellular vesicles in oxi-inflamm-aging related to cardiorenal syndrome
AU - Mas-Bargues, Cristina
AU - Alique, Matilde
AU - Barrús-Ortiz, María Teresa
AU - Borrás, Consuelo
AU - Rodrigues-Díez, Raquel
N1 - Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/1
Y1 - 2022/1
N2 - The incidence of age associated chronic diseases has increased in recent years. Although several diverse causes produce these phenomena, abundant evidence shows that oxidative stress plays a central role. In recent years, numerous studies have focused on elucidating the role of oxidative stress in the development and progression of both aging and chronic diseases, opening the door to the discovery of new underlying mechanisms and signaling pathways. Among them, senolytics and senomorphics, and extracellular vesicles offer new therapeutic strategies to slow the development of aging and its associated chronic diseases by decreasing oxidative stress. In this review, we aim to discuss the role of extracellular vesicles in human cardiorenal syndrome development and their possible role as biomarkers, targets, or vehicles of drugs to treat this syndrome.
AB - The incidence of age associated chronic diseases has increased in recent years. Although several diverse causes produce these phenomena, abundant evidence shows that oxidative stress plays a central role. In recent years, numerous studies have focused on elucidating the role of oxidative stress in the development and progression of both aging and chronic diseases, opening the door to the discovery of new underlying mechanisms and signaling pathways. Among them, senolytics and senomorphics, and extracellular vesicles offer new therapeutic strategies to slow the development of aging and its associated chronic diseases by decreasing oxidative stress. In this review, we aim to discuss the role of extracellular vesicles in human cardiorenal syndrome development and their possible role as biomarkers, targets, or vehicles of drugs to treat this syndrome.
KW - Age-related pathologies
KW - Aging
KW - Extracellular vesicles
KW - Inflammation
KW - Oxi-inflamm-aging
KW - Oxidative stress
KW - Senescence
KW - Senolytics
UR - https://www.scopus.com/pages/publications/85121811987
U2 - 10.3390/antiox11010078
DO - 10.3390/antiox11010078
M3 - Review article
AN - SCOPUS:85121811987
SN - 2076-3921
VL - 11
JO - Antioxidants
JF - Antioxidants
IS - 1
M1 - 78
ER -