TY - GEN
T1 - Exploration of acute effects of stimulation frequency on subcallosal cingulate dynamics in SCC DBS
AU - Fitoz, Elif Ceren
AU - Alagapan, Sankaraleengam
AU - Waters, Allison
AU - Tiruvadi, Vineet
AU - Veerakumar, Ashan
AU - Obatusin, Mosadoluwa
AU - Choi, Ki Sueng
AU - Crowell, Andrea
AU - Riva-Posse, Patricio
AU - Butera, Robert
AU - Mayberg, Helen
AU - Rozell, Christopher
N1 - Publisher Copyright:
© 2023 IEEE.
PY - 2023
Y1 - 2023
N2 - Deep Brain Stimulation (DBS) of the subcallosal cingulate cortex (SCC) is effective in treating patients with treatment-resistant depression. While the stimulation intensity (voltage, current) is often changed during therapy, the stimulation frequency is often set to be constant at 130 Hz, as the effect of stimulation frequency on SCC dynamics is unclear. The purpose of this study was to examine the acute effects of different stimulation frequencies on local field potentials (LFP) recorded from ten patients who underwent chronic SCC stimulation to treat TRD. In the experiment, short pulse trains of 2 minutes duration and 6V amplitude were used, with frequencies varying monotonically between 10 and 130 Hz. The spectral power change computed for canonical frequency bands (delta, theta, alpha, beta, and gamma) during post stimulation offset. While we did not find a significant effect of stimulation frequency, we observed a difference in responses to acute stimulation in beta and gamma bands, between patients who had undergone chronic stimulation and those who had not. Moreover, we investigated the predictive nature of acute changes in right hemisphere gamma oscillations on treatment outcome. Our results suggest that stimulation frequency may not be significant factor determining outlasting effects of acute stimulation. Furthermore, chronic DBS may contribute to an adaptive process at the local circuit level.
AB - Deep Brain Stimulation (DBS) of the subcallosal cingulate cortex (SCC) is effective in treating patients with treatment-resistant depression. While the stimulation intensity (voltage, current) is often changed during therapy, the stimulation frequency is often set to be constant at 130 Hz, as the effect of stimulation frequency on SCC dynamics is unclear. The purpose of this study was to examine the acute effects of different stimulation frequencies on local field potentials (LFP) recorded from ten patients who underwent chronic SCC stimulation to treat TRD. In the experiment, short pulse trains of 2 minutes duration and 6V amplitude were used, with frequencies varying monotonically between 10 and 130 Hz. The spectral power change computed for canonical frequency bands (delta, theta, alpha, beta, and gamma) during post stimulation offset. While we did not find a significant effect of stimulation frequency, we observed a difference in responses to acute stimulation in beta and gamma bands, between patients who had undergone chronic stimulation and those who had not. Moreover, we investigated the predictive nature of acute changes in right hemisphere gamma oscillations on treatment outcome. Our results suggest that stimulation frequency may not be significant factor determining outlasting effects of acute stimulation. Furthermore, chronic DBS may contribute to an adaptive process at the local circuit level.
KW - SCC
KW - deep brain stimulation
KW - depression
KW - local field potentials
UR - https://www.scopus.com/pages/publications/85160640088
U2 - 10.1109/NER52421.2023.10123785
DO - 10.1109/NER52421.2023.10123785
M3 - Conference contribution
AN - SCOPUS:85160640088
T3 - International IEEE/EMBS Conference on Neural Engineering, NER
BT - 11th International IEEE/EMBS Conference on Neural Engineering, NER 2023 - Proceedings
PB - IEEE Computer Society
T2 - 11th International IEEE/EMBS Conference on Neural Engineering, NER 2023
Y2 - 25 April 2023 through 27 April 2023
ER -