Exploration of acute effects of stimulation frequency on subcallosal cingulate dynamics in SCC DBS

Elif Ceren Fitoz, Sankaraleengam Alagapan, Allison Waters, Vineet Tiruvadi, Ashan Veerakumar, Mosadoluwa Obatusin, Ki Sueng Choi, Andrea Crowell, Patricio Riva-Posse, Robert Butera, Helen Mayberg, Christopher Rozell

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Deep Brain Stimulation (DBS) of the subcallosal cingulate cortex (SCC) is effective in treating patients with treatment-resistant depression. While the stimulation intensity (voltage, current) is often changed during therapy, the stimulation frequency is often set to be constant at 130 Hz, as the effect of stimulation frequency on SCC dynamics is unclear. The purpose of this study was to examine the acute effects of different stimulation frequencies on local field potentials (LFP) recorded from ten patients who underwent chronic SCC stimulation to treat TRD. In the experiment, short pulse trains of 2 minutes duration and 6V amplitude were used, with frequencies varying monotonically between 10 and 130 Hz. The spectral power change computed for canonical frequency bands (delta, theta, alpha, beta, and gamma) during post stimulation offset. While we did not find a significant effect of stimulation frequency, we observed a difference in responses to acute stimulation in beta and gamma bands, between patients who had undergone chronic stimulation and those who had not. Moreover, we investigated the predictive nature of acute changes in right hemisphere gamma oscillations on treatment outcome. Our results suggest that stimulation frequency may not be significant factor determining outlasting effects of acute stimulation. Furthermore, chronic DBS may contribute to an adaptive process at the local circuit level.

Original languageEnglish
Title of host publication11th International IEEE/EMBS Conference on Neural Engineering, NER 2023 - Proceedings
PublisherIEEE Computer Society
ISBN (Electronic)9781665462921
DOIs
StatePublished - 2023
Event11th International IEEE/EMBS Conference on Neural Engineering, NER 2023 - Baltimore, United States
Duration: 25 Apr 202327 Apr 2023

Publication series

NameInternational IEEE/EMBS Conference on Neural Engineering, NER
Volume2023-April
ISSN (Print)1948-3546
ISSN (Electronic)1948-3554

Conference

Conference11th International IEEE/EMBS Conference on Neural Engineering, NER 2023
Country/TerritoryUnited States
CityBaltimore
Period25/04/2327/04/23

Keywords

  • SCC
  • deep brain stimulation
  • depression
  • local field potentials

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