Exploiting dendritic cells for active immunotherapy of cancer and chronic infection.

David O'Neill, Nina Bhardwaj

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations

Abstract

Dendritic cells (DC) are important antigen-presenting cells (APC) that can prime naive T-cells and control lymphocyte-mediated adaptive immune responses with respect to magnitude, memory, and self-tolerance. Understanding the biology of these cells is central to the development of new generation immunotherapies for cancer and chronic infection. This chapter presents a brief overview of DC biology and the preparation and use of DC-based vaccines.

Original languageEnglish
Pages (from-to)1-18
Number of pages18
JournalMethods in molecular medicine
Volume109
StatePublished - 2005
Externally publishedYes

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