@article{2d8c3eca966c405b8aba04e5cfa94b64,
title = "Exploiting and antagonizing microRNA regulation for therapeutic and experimental applications",
abstract = "New technologies are emerging that utilize artificial microRNA (miRNA) target sites to exploit or inhibit endogenous miRNA regulation. This approach has been used to improve cell-specific targeting for gene and stem cell therapy studies and for animal transgenics, and also to reduce the toxicity of oncolytic viruses and to attenuate viral vaccines. Artificial targets have also been used to sponge or decoy miRNAs as a way to study their functions. This article considers the benefits of this approach and design considerations for future studies.",
author = "Brown, {Brian D.} and Luigi Naldini",
note = "Funding Information: We would like to thank A. Baccarini, R. Sachidanandam, A. Lombardo, M. De Palma, A. Cantore and B. Gentner for discussions. We apologize to those whose relevant work was not cited here. B.D.B. is supported by the National Institutes for Health (NIH) Diabetes Pathfinder Award (DP2DK083052-01) and L.N. is supported by Fondazione Telethon, the European Union (PERSIST, CONSERT, RIGHT) the NIH, and Associazione Italiana per la Ricerca Sal Cancro.",
year = "2009",
month = aug,
doi = "10.1038/nrg2628",
language = "English",
volume = "10",
pages = "578--585",
journal = "Nature Reviews Genetics",
issn = "1471-0056",
publisher = "Nature Publishing Group",
number = "8",
}