Expert Consensus on the Use of On-Demand Treatments for OFF Episodes in Parkinson's Disease: A Modified Delphi Panel

Stuart H. Isaacson; Madhureeta Achari; Roongroj Bhidayasiri; Cynthia Comella; Jill Giordano Farmer; Fiona Gupta; Sarah Jones; David Kreitzman; Daniel Kremens; Simon J.G. Lewis; Werner Poewe; Eduardo Tolosa; Cynthia Campos; Sarah N. Gibbs; Michael S. Broder

doi:10.1002/mdc3.13690

Expert Consensus on the Use of On-Demand Treatments for OFF Episodes in Parkinson's Disease: A Modified Delphi Panel

Stuart H. Isaacson
, Madhureeta Achari
, Roongroj Bhidayasiri
, Cynthia Comella
, Jill Giordano Farmer
, Fiona Gupta
, Sarah Jones
, David Kreitzman
, Daniel Kremens
, Simon J.G. Lewis
, Werner Poewe
, Eduardo Tolosa
, Cynthia Campos
, Sarah N. Gibbs
, Michael S. Broder

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Background: On-demand treatments can treat OFF episodes in Parkinson's disease, however, there is limited information regarding when to prescribe them. Objective: Develop expert consensus to determine appropriate clinical factors for considering on-demand treatments. Methods: Using a RAND/UCLA modified Delphi panel method, a panel developed consensus on the use of on-demand treatments for OFF episodes. Results: The panel agreed on-demand treatments were appropriate when OFF episodes were associated with greater functional impact and interfered with basic daily activities. The panel also agreed on-demand treatment may be appropriate for patients with morning akinesia and/or delayed ON of first levodopa dose and >1 type of OFF episode (eg, early morning OFF or wearing OFF regardless of frequency). Conclusions: Experts agreed on-demand treatment is appropriate for many patients with OFF episodes. The greater the functional impact of OFF episodes, the more likely experts agreed that on-demand treatment is appropriate to prescribe.

Original language	English
Pages (from-to)	652-657
Number of pages	6
Journal	Movement Disorders Clinical Practice
Volume	10
Issue number	4
DOIs	https://doi.org/10.1002/mdc3.13690
State	Published - Apr 2023

Keywords

OFF episode
Parkinson's disease
movement disorderneurology
on-demand treatment

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10.1002/mdc3.13690

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Isaacson, S. H., Achari, M., Bhidayasiri, R., Comella, C., Farmer, J. G., Gupta, F., Jones, S., Kreitzman, D., Kremens, D., Lewis, S. J. G., Poewe, W., Tolosa, E., Campos, C., Gibbs, S. N., & Broder, M. S. (2023). Expert Consensus on the Use of On-Demand Treatments for OFF Episodes in Parkinson's Disease: A Modified Delphi Panel. Movement Disorders Clinical Practice, 10(4), 652-657. https://doi.org/10.1002/mdc3.13690

@article{006180bb35574eb19585c6bb2fb7db66,

title = "Expert Consensus on the Use of On-Demand Treatments for OFF Episodes in Parkinson's Disease: A Modified Delphi Panel",

abstract = "Background: On-demand treatments can treat OFF episodes in Parkinson's disease, however, there is limited information regarding when to prescribe them. Objective: Develop expert consensus to determine appropriate clinical factors for considering on-demand treatments. Methods: Using a RAND/UCLA modified Delphi panel method, a panel developed consensus on the use of on-demand treatments for OFF episodes. Results: The panel agreed on-demand treatments were appropriate when OFF episodes were associated with greater functional impact and interfered with basic daily activities. The panel also agreed on-demand treatment may be appropriate for patients with morning akinesia and/or delayed ON of first levodopa dose and >1 type of OFF episode (eg, early morning OFF or wearing OFF regardless of frequency). Conclusions: Experts agreed on-demand treatment is appropriate for many patients with OFF episodes. The greater the functional impact of OFF episodes, the more likely experts agreed that on-demand treatment is appropriate to prescribe.",

keywords = "OFF episode, Parkinson's disease, movement disorderneurology, on-demand treatment",

author = "Isaacson, \{Stuart H.\} and Madhureeta Achari and Roongroj Bhidayasiri and Cynthia Comella and Farmer, \{Jill Giordano\} and Fiona Gupta and Sarah Jones and David Kreitzman and Daniel Kremens and Lewis, \{Simon J.G.\} and Werner Poewe and Eduardo Tolosa and Cynthia Campos and Gibbs, \{Sarah N.\} and Broder, \{Michael S.\}",

note = "Publisher Copyright: {\textcopyright} 2023 Sunovion Pharmaceuticals Inc. Movement Disorders Clinical Practice published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.",

year = "2023",

month = apr,

doi = "10.1002/mdc3.13690",

language = "English",

volume = "10",

pages = "652--657",

journal = "Movement Disorders Clinical Practice",

issn = "2330-1619",

publisher = "John Wiley and Sons Ltd",

number = "4",

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Isaacson, SH, Achari, M, Bhidayasiri, R, Comella, C, Farmer, JG, Gupta, F, Jones, S, Kreitzman, D, Kremens, D, Lewis, SJG, Poewe, W, Tolosa, E, Campos, C, Gibbs, SN & Broder, MS 2023, 'Expert Consensus on the Use of On-Demand Treatments for OFF Episodes in Parkinson's Disease: A Modified Delphi Panel', Movement Disorders Clinical Practice, vol. 10, no. 4, pp. 652-657. https://doi.org/10.1002/mdc3.13690

TY - JOUR

T1 - Expert Consensus on the Use of On-Demand Treatments for OFF Episodes in Parkinson's Disease

T2 - A Modified Delphi Panel

AU - Isaacson, Stuart H.

AU - Achari, Madhureeta

AU - Bhidayasiri, Roongroj

AU - Comella, Cynthia

AU - Farmer, Jill Giordano

AU - Gupta, Fiona

AU - Jones, Sarah

AU - Kreitzman, David

AU - Kremens, Daniel

AU - Lewis, Simon J.G.

AU - Poewe, Werner

AU - Tolosa, Eduardo

AU - Campos, Cynthia

AU - Gibbs, Sarah N.

AU - Broder, Michael S.

N1 - Publisher Copyright: © 2023 Sunovion Pharmaceuticals Inc. Movement Disorders Clinical Practice published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

PY - 2023/4

Y1 - 2023/4

N2 - Background: On-demand treatments can treat OFF episodes in Parkinson's disease, however, there is limited information regarding when to prescribe them. Objective: Develop expert consensus to determine appropriate clinical factors for considering on-demand treatments. Methods: Using a RAND/UCLA modified Delphi panel method, a panel developed consensus on the use of on-demand treatments for OFF episodes. Results: The panel agreed on-demand treatments were appropriate when OFF episodes were associated with greater functional impact and interfered with basic daily activities. The panel also agreed on-demand treatment may be appropriate for patients with morning akinesia and/or delayed ON of first levodopa dose and >1 type of OFF episode (eg, early morning OFF or wearing OFF regardless of frequency). Conclusions: Experts agreed on-demand treatment is appropriate for many patients with OFF episodes. The greater the functional impact of OFF episodes, the more likely experts agreed that on-demand treatment is appropriate to prescribe.

AB - Background: On-demand treatments can treat OFF episodes in Parkinson's disease, however, there is limited information regarding when to prescribe them. Objective: Develop expert consensus to determine appropriate clinical factors for considering on-demand treatments. Methods: Using a RAND/UCLA modified Delphi panel method, a panel developed consensus on the use of on-demand treatments for OFF episodes. Results: The panel agreed on-demand treatments were appropriate when OFF episodes were associated with greater functional impact and interfered with basic daily activities. The panel also agreed on-demand treatment may be appropriate for patients with morning akinesia and/or delayed ON of first levodopa dose and >1 type of OFF episode (eg, early morning OFF or wearing OFF regardless of frequency). Conclusions: Experts agreed on-demand treatment is appropriate for many patients with OFF episodes. The greater the functional impact of OFF episodes, the more likely experts agreed that on-demand treatment is appropriate to prescribe.

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KW - Parkinson's disease

KW - movement disorderneurology

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AN - SCOPUS:85150623216

SN - 2330-1619

VL - 10

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EP - 657

JO - Movement Disorders Clinical Practice

JF - Movement Disorders Clinical Practice

IS - 4

ER -

Expert Consensus on the Use of On-Demand Treatments for OFF Episodes in Parkinson's Disease: A Modified Delphi Panel

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Keywords

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