TY - JOUR
T1 - Experimental visna in foetal Icelandic sheep
AU - Georgsson, G.
AU - Pétursson, G.
AU - Miller, A.
AU - Nathanson, N.
AU - Pálsson, P. A.
N1 - Funding Information:
We wish to thank Miss A. Gunnlaugsdottir, Mrs E. Benediktsdottir, Miss E. Gisladcittir, Miss K. Kristinsdottir, Miss N. Naudot and K. Lutley for technical assistance. The study was supported in part by grant NS 11451 from the USPHS.
PY - 1978/10
Y1 - 1978/10
N2 - Visna is a chronic neurological disease of sheep caused by a slow infection with a naturally occurring ovine retrovirus. The present study was focused on the influence of age on the pathogenesis of this infection and involved intrauterine inoculation of 7 sheep foetuses at about 90 days of gestation with slaughter at birth, 6 to 7 weeks later. The results were compared with prior observations in newborn lambs and adult sheep infected with the same visna virus strain. Pathological lesions of the CNS in foetal sheep were of similar character, localization and severity as those in both newborn and adult sheep. The distribution of virus, the generally low titres of free infectious virus, and the requirement for explantation to isolate virus in some instances, were similar in foetal and in older sheep. However, the more frequent virus isolations from foetal and newborn sheep indicate a slightly greater permissiveness for virus replication. In general, age apparently has little effect on the course of this slow infection.
AB - Visna is a chronic neurological disease of sheep caused by a slow infection with a naturally occurring ovine retrovirus. The present study was focused on the influence of age on the pathogenesis of this infection and involved intrauterine inoculation of 7 sheep foetuses at about 90 days of gestation with slaughter at birth, 6 to 7 weeks later. The results were compared with prior observations in newborn lambs and adult sheep infected with the same visna virus strain. Pathological lesions of the CNS in foetal sheep were of similar character, localization and severity as those in both newborn and adult sheep. The distribution of virus, the generally low titres of free infectious virus, and the requirement for explantation to isolate virus in some instances, were similar in foetal and in older sheep. However, the more frequent virus isolations from foetal and newborn sheep indicate a slightly greater permissiveness for virus replication. In general, age apparently has little effect on the course of this slow infection.
UR - https://www.scopus.com/pages/publications/0018168796
U2 - 10.1016/0021-9975(78)90013-0
DO - 10.1016/0021-9975(78)90013-0
M3 - Article
C2 - 213455
AN - SCOPUS:0018168796
SN - 0021-9975
VL - 88
SP - 597
EP - 605
JO - Journal of Comparative Pathology
JF - Journal of Comparative Pathology
IS - 4
ER -