Experimental protocols for mri mapping of renal t1

Philippe Garteiser, Octavia Bane, Sabrina Doblas, Iris Friedli, Stefanie Hectors, Gwenaël Pagé, Bernard E. Van Beers, John C. Waterton

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Scopus citations

Abstract

The water proton longitudinal relaxation time, T1, is a common and useful MR parameter in nephrology research. Here we provide three step-by-step T1-mapping protocols suitable for different types of nephrology research. Firstly, we provide a single-slice 2D saturation recovery protocol suitable for studies of global pathology, where whole-kidney coverage is unnecessary. Secondly, we provide an inversion recovery type imaging protocol that may be optimized for specific kidney disease applications. Finally, we also provide imaging protocol for small animal kidney imaging in a clinical scanner. This chapter is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers. This analysis protocol chapter is complemented by two separate chapters describing the basic concept and experimental procedure.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages383-402
Number of pages20
DOIs
StatePublished - 2021

Publication series

NameMethods in Molecular Biology
Volume2216
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Keywords

  • Kidney
  • Longitudinal relaxation time (T)
  • Magnetic resonance imaging (MRI)
  • Mice
  • Rats
  • Spin-lattice relaxation time (T)

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