Hepatocellular carcinoma (HCC) is a common and deadly cancer whose pathogenesis is incompletely understood. Comparative genomic studies from human HCC samples have classified HCCs into different molecular subgroups; yet, the unifying feature of this tumor is its propensity to arise upon a background of inflammation and fibrosis. This review seeks to analyze the available experimental models in HCC research and to correlate data from human populations with them in order to consolidate our efforts to date, as it is increasingly clear that different models will be required to mimic different subclasses of the neoplasm. These models will be instrumental in the evaluation of compounds targeting specific molecular pathways in future preclinical studies.

Original languageEnglish
Pages (from-to)858-879
Number of pages22
JournalJournal of Hepatology
Issue number5
StatePublished - May 2008


  • Cirrhosis
  • Genetically engineered mice
  • Hepatocellular carcinoma
  • Liver cancer
  • Mouse models


Dive into the research topics of 'Experimental models of hepatocellular carcinoma'. Together they form a unique fingerprint.

Cite this