Experimental models of cardiovascular diseases: Overview

Jae Gyun Oh, Kiyotake Ishikawa

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

17 Scopus citations

Abstract

Cardiovascular disease is one of the most common causes of deaths in clinics. Experimental models of cardiovascular diseases are essential to understand disease mechanism, to provide accurate diagnoses, and to develop new therapies. Large numbers of experimental models have been proposed and replicated by many laboratories in the past. Models with significant advantages are chosen and became more popular. Particularly, feasibility, reproducibility, and human disease resemblance are the common, key factors for, frequently used cardiovascular disease models. In this chapter, we provide a brief overview of these experimental models used, for in vitro, in vivo, and in silico studies of cardiovascular diseases.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages3-14
Number of pages12
DOIs
StatePublished - 2018

Publication series

NameMethods in Molecular Biology
Volume1816
ISSN (Print)1064-3745

Keywords

  • Animal model
  • Cardiomyocyte
  • Electrophysiology
  • Heart failure
  • Large animals
  • Left ventricle
  • Modeling
  • Myocardial infarction
  • Pulmonary hypertension
  • Rodents

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