Experimental models of cardiac physiology and pathology

Jae Gyun Oh; Changwon Kho; Roger J. Hajjar; Kiyotake Ishikawa

doi:10.1007/s10741-019-09769-2

Experimental models of cardiac physiology and pathology

Jae Gyun Oh, Changwon Kho, Roger J. Hajjar, Kiyotake Ishikawa

Research output: Contribution to journal › Review article › peer-review

17 Scopus citations

Abstract

Experimental models of cardiac disease play a key role in understanding the pathophysiology of the disease and developing new therapies. The features of the experimental models should reflect the clinical phenotype, which can have a wide spectrum of underlying mechanisms. We review characteristics of commonly used experimental models of cardiac physiology and pathophysiology in all translational steps including in vitro, small animal, and large animal models. Understanding their characteristics and relevance to clinical disease is the key for successful translation to effective therapies.

Original language	English
Pages (from-to)	601-615
Number of pages	15
Journal	Heart Failure Reviews
Volume	24
Issue number	4
DOIs	https://doi.org/10.1007/s10741-019-09769-2
State	Published - 15 Jul 2019

Keywords

Ischemic
Neonatal cardiomyocytes
Non-ischemic
Pressure overload
Primary cardiomyocytes
Volume overload

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10.1007/s10741-019-09769-2

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title = "Experimental models of cardiac physiology and pathology",

abstract = "Experimental models of cardiac disease play a key role in understanding the pathophysiology of the disease and developing new therapies. The features of the experimental models should reflect the clinical phenotype, which can have a wide spectrum of underlying mechanisms. We review characteristics of commonly used experimental models of cardiac physiology and pathophysiology in all translational steps including in vitro, small animal, and large animal models. Understanding their characteristics and relevance to clinical disease is the key for successful translation to effective therapies.",

keywords = "Ischemic, Neonatal cardiomyocytes, Non-ischemic, Pressure overload, Primary cardiomyocytes, Volume overload",

author = "Oh, {Jae Gyun} and Changwon Kho and Hajjar, {Roger J.} and Kiyotake Ishikawa",

note = "Funding Information: Funding information This work is supported by AHA-SDG 17SDG33410873 (K.I.), and AHA 17POST33410877 (J.G.O.), NIH R01 HL139963 (K.I.), AHA-18TPA34170460 (C.K.), R00 HL116645 (C.K.), R01 HL119046, R01 HL117505, R01 HL128099, R01 HL129814, R01HL131404, & T32 HL007824 (R. J. H.), and a Transatlantic Leducq Foundation grant. Publisher Copyright: {\textcopyright} 2019, Springer Science+Business Media, LLC, part of Springer Nature.",

year = "2019",

month = jul,

day = "15",

doi = "10.1007/s10741-019-09769-2",

language = "English",

volume = "24",

pages = "601--615",

journal = "Heart Failure Reviews",

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AU - Oh, Jae Gyun

AU - Kho, Changwon

AU - Hajjar, Roger J.

AU - Ishikawa, Kiyotake

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Y1 - 2019/7/15

N2 - Experimental models of cardiac disease play a key role in understanding the pathophysiology of the disease and developing new therapies. The features of the experimental models should reflect the clinical phenotype, which can have a wide spectrum of underlying mechanisms. We review characteristics of commonly used experimental models of cardiac physiology and pathophysiology in all translational steps including in vitro, small animal, and large animal models. Understanding their characteristics and relevance to clinical disease is the key for successful translation to effective therapies.

AB - Experimental models of cardiac disease play a key role in understanding the pathophysiology of the disease and developing new therapies. The features of the experimental models should reflect the clinical phenotype, which can have a wide spectrum of underlying mechanisms. We review characteristics of commonly used experimental models of cardiac physiology and pathophysiology in all translational steps including in vitro, small animal, and large animal models. Understanding their characteristics and relevance to clinical disease is the key for successful translation to effective therapies.

KW - Ischemic

KW - Neonatal cardiomyocytes

KW - Non-ischemic

KW - Pressure overload

KW - Primary cardiomyocytes

KW - Volume overload

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EP - 615

JO - Heart Failure Reviews

JF - Heart Failure Reviews

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Experimental models of cardiac physiology and pathology

Abstract

Keywords

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