Experimental models of cardiac physiology and pathology

Jae Gyun Oh, Changwon Kho, Roger J. Hajjar, Kiyotake Ishikawa

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


Experimental models of cardiac disease play a key role in understanding the pathophysiology of the disease and developing new therapies. The features of the experimental models should reflect the clinical phenotype, which can have a wide spectrum of underlying mechanisms. We review characteristics of commonly used experimental models of cardiac physiology and pathophysiology in all translational steps including in vitro, small animal, and large animal models. Understanding their characteristics and relevance to clinical disease is the key for successful translation to effective therapies.

Original languageEnglish
Pages (from-to)601-615
Number of pages15
JournalHeart Failure Reviews
Issue number4
StatePublished - 15 Jul 2019


  • Ischemic
  • Neonatal cardiomyocytes
  • Non-ischemic
  • Pressure overload
  • Primary cardiomyocytes
  • Volume overload


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