Over the past 15 years, a number of new clinical and experimental approaches have evolved which have begun to provide insights into the causes of alveolar destruction. This review is an account of the development of ideas in the area of experimental emphysema. Through multidisciplinary approaches to pathogenetic mechanisms in emphysema using experimental animals as well as the human disease as models, some progress is being made in defining the interactions of chemical, physical and morphological relationships underlying the lung parenchymal destruction. However, an overly restricted and simplified view of the mechanisms which alter lung tissue in chronic obstructive lung disease may defer comprehensive understanding of the many pathogenetic pathways by which pulmonary emphysema evolves in human disease.
|Number of pages||7|
|Journal||Clinical Respiratory Physiology|
|State||Published - 1977|