Experimental basis and clinical studies of brain protection in aortic arch surgery

Gabriele Di Luozzo, Randall B. Griepp

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Scopus citations


The management of complex aortic arch disease has been and continues to be dependent upon reproducible neuronal protection strategies. Over the last 2 decades, numerous brain protection strategies have been investigated and employed in clinical practice. Since 1975, prolonged interruption of antegrade brain perfusion for the resection of aortic arch and ascending aortic aneurysms has relied principally on hypothermic circulatory arrest (HCA).1 This method of brain protection has been embraced and still remains the primary brain protection strategy used by adult and pediatric cardiac surgeons worldwide. As surgical techniques have become more sophisticated, and our understanding of brain metabolism has improved, however, other strategies for brain protection have been introduced. Regardless of the methodology, the common denominator in almost all the strategies is hypothermia.

Original languageEnglish
Title of host publicationBrain Protection in Cardiac Surgery
PublisherSpringer London
Number of pages10
ISBN (Print)9781849962926
StatePublished - 2011


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