TY - JOUR
T1 - Exosomal miRNAs in urine associated with children's cardiorenal parameters
T2 - A cross-sectional study
AU - Levin-Schwartz, Yuri
AU - Curtin, Paul
AU - Flores, Daniel
AU - Aushev, Vasily N.
AU - Tamayo-Ortiz, Marcela
AU - Svensson, Katherine
AU - Pantic, Ivan
AU - Estrada-Gutierrez, Guadalupe
AU - Pizano-Zárate, María L.
AU - Gennings, Chris
AU - Satlin, Lisa M.
AU - Baccarelli, Andrea A.
AU - Tellez-Rojo, Martha M.
AU - Wright, Robert O.
AU - Sanders, Alison P.
N1 - Publisher Copyright:
© 2021 Future Medicine Ltd.. All rights reserved.
PY - 2021/4
Y1 - 2021/4
N2 - Aims: The authors sought to examine associations between urinary exosomal miRNAs (exo-miRs), emerging biomarkers of renal health, and cardiorenal outcomes in early childhood. Materials & methods: The authors extracted exo-miRs in urine from 88 healthy Mexican children aged 4-6 years. The authors measured associations between 193 exo-miRs and cardiorenal outcomes: systolic/diastolic blood pressure, estimated glomerular filtration rate and urinary sodium and potassium levels. The authors adjusted for age, sex, BMI, socioeconomic status, indoor tobacco smoke exposure and urine specific gravity. Results: Multiple exo-miRs were identified meeting a false discovery rate threshold of q < 0.1. Specifically, three exo-miRs had increased expression with urinary sodium, 17 with urinary sodium-to-potassium ratio and one with decreased estimated glomerular filtration rate. Conclusions: These results highlight urinary exo-miRs as early-life biomarkers of children's cardiorenal health.
AB - Aims: The authors sought to examine associations between urinary exosomal miRNAs (exo-miRs), emerging biomarkers of renal health, and cardiorenal outcomes in early childhood. Materials & methods: The authors extracted exo-miRs in urine from 88 healthy Mexican children aged 4-6 years. The authors measured associations between 193 exo-miRs and cardiorenal outcomes: systolic/diastolic blood pressure, estimated glomerular filtration rate and urinary sodium and potassium levels. The authors adjusted for age, sex, BMI, socioeconomic status, indoor tobacco smoke exposure and urine specific gravity. Results: Multiple exo-miRs were identified meeting a false discovery rate threshold of q < 0.1. Specifically, three exo-miRs had increased expression with urinary sodium, 17 with urinary sodium-to-potassium ratio and one with decreased estimated glomerular filtration rate. Conclusions: These results highlight urinary exo-miRs as early-life biomarkers of children's cardiorenal health.
KW - adolescence
KW - blood pressure
KW - childhood
KW - exosome
KW - extracellular vesicle
KW - kidney
KW - potassium
KW - sodium
UR - http://www.scopus.com/inward/record.url?scp=85103950971&partnerID=8YFLogxK
U2 - 10.2217/epi-2020-0342
DO - 10.2217/epi-2020-0342
M3 - Article
C2 - 33635093
AN - SCOPUS:85103950971
SN - 1750-1911
VL - 13
SP - 499
EP - 512
JO - Epigenomics
JF - Epigenomics
IS - 7
ER -