Executive function and cerebrovascular reactivity in pediatric hypertension

Maria A. Ostrovskaya, Mary Rojas, Juan C. Kupferman, Marc B. Lande, Kara Paterno, Yuri Brosgol, Steven G. Pavlakis

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Primary hypertension is associated with decreased performance on neurocognitive testing and a blunted cerebrovascular reactivity to hypercapnia. Parents of 14 children with hypertension and prehypertension completed the Behavior Rating Inventory of Executive Functions. Children underwent 24-hour ambulatory blood pressure monitoring and transcranial Doppler with reactivity measurement using time-averaged maximum mean velocity and end-tidal carbon dioxide during hypercapnia-rebreathing test. Comparing the reactivity slope for the patients to historical controls showed a statistically significant difference (t = -5.19, df = 13, P <.001), with lower slopes. Pearson correlations of the Behavior Rating Inventory of Executive Functions scores with the reactivity slopes showed a statistically significant inverse relationship with Behavioral Regulation Index (r = -.60, P =.02), Metacognition Index (r = -.40, P =.05), and the Global Executive Component (r = -.53, P =.05). Children with hypertension have decreased executive function, and this correlates to low transcranial Doppler-reactivity slopes, suggesting that the brain is a target organ in hypertensive children.

Original languageEnglish
Pages (from-to)543-546
Number of pages4
JournalJournal of Child Neurology
Issue number5
StatePublished - 27 Apr 2015
Externally publishedYes


  • cognition
  • hypertension
  • transcranial Doppler


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