Exclusion mapping in familial non-specific dementia

J. Brown; S. Gydesen; S. A. Sorensen; A. Brun; K. Duff; H. Houlden; L. Fidani; S. Kullkarni; J. Cummings; A. Goate; M. Rossor; J. Hardy

doi:10.1159/000107317

Exclusion mapping in familial non-specific dementia

J. Brown
, S. Gydesen
, S. A. Sorensen
, A. Brun
, K. Duff
, H. Houlden
, L. Fidani
, S. Kullkarni
, J. Cummings
, A. Goate
, M. Rossor
, J. Hardy

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

We present genetic linkage data in a large family in which non-specific dementia is inherited as an autosomal dominant trait. We have analyzed 45 highly polymorphic microsatellite sequences and excluded a quarter of the genome as the site of the pathogenic mutation in this family.

Original language	English
Pages (from-to)	163-166
Number of pages	4
Journal	Dementia
Volume	4
Issue number	3-4
DOIs	https://doi.org/10.1159/000107317
State	Published - 1993
Externally published	Yes

Keywords

Frontal lobe dementia
Linkage analysis
Microsatellite sequences
Non-specific dementia
Pick's disease

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10.1159/000107317

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title = "Exclusion mapping in familial non-specific dementia",

abstract = "We present genetic linkage data in a large family in which non-specific dementia is inherited as an autosomal dominant trait. We have analyzed 45 highly polymorphic microsatellite sequences and excluded a quarter of the genome as the site of the pathogenic mutation in this family.",

keywords = "Frontal lobe dementia, Linkage analysis, Microsatellite sequences, Non-specific dementia, Pick's disease",

author = "J. Brown and S. Gydesen and Sorensen, \{S. A.\} and A. Brun and K. Duff and H. Houlden and L. Fidani and S. Kullkarni and J. Cummings and A. Goate and M. Rossor and J. Hardy",

year = "1993",

doi = "10.1159/000107317",

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volume = "4",

pages = "163--166",

journal = "Dementia",

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T1 - Exclusion mapping in familial non-specific dementia

AU - Brown, J.

AU - Gydesen, S.

AU - Sorensen, S. A.

AU - Brun, A.

AU - Duff, K.

AU - Houlden, H.

AU - Fidani, L.

AU - Kullkarni, S.

AU - Cummings, J.

AU - Goate, A.

AU - Rossor, M.

AU - Hardy, J.

PY - 1993

Y1 - 1993

N2 - We present genetic linkage data in a large family in which non-specific dementia is inherited as an autosomal dominant trait. We have analyzed 45 highly polymorphic microsatellite sequences and excluded a quarter of the genome as the site of the pathogenic mutation in this family.

AB - We present genetic linkage data in a large family in which non-specific dementia is inherited as an autosomal dominant trait. We have analyzed 45 highly polymorphic microsatellite sequences and excluded a quarter of the genome as the site of the pathogenic mutation in this family.

KW - Frontal lobe dementia

KW - Linkage analysis

KW - Microsatellite sequences

KW - Non-specific dementia

KW - Pick's disease

UR - https://www.scopus.com/pages/publications/0027244192

U2 - 10.1159/000107317

DO - 10.1159/000107317

M3 - Article

C2 - 8401786

AN - SCOPUS:0027244192

SN - 1013-7424

VL - 4

SP - 163

EP - 166

JO - Dementia

JF - Dementia

IS - 3-4

ER -

Exclusion mapping in familial non-specific dementia

Abstract

Keywords

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