Examining the nature of the association between attention-deficit hyperactivity disorder and nicotine dependence: A familial risk analysis

Joseph Biederman, Carter R. Petty, Paul Hammerness, K. Yvonne Woodworth, Stephen V. Faraone

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Objective: To use familial risk analysis to examine the association between attention-deficit hyperactivity disorder (ADHD) and nicotine dependence (ND). Method: Subjects were children with (n = 257) and without (n = 229) ADHD of both sexes ascertained from pediatric and psychiatric referral sources and their first-degree relatives (N = 1627). Results: ND in probands increased the risk for ND in relatives irrespective of ADHD status. There was no evidence of cosegregation or assortative mating between these disorders. Patterns of familial risk analysis suggest that the association between ADHD and ND is most consistent with the hypothesis of independent transmission of these disorders. Conclusions: These findings may have important implications for the identification of a subgroup of children with ADHD at high risk for ND based on parental history of ND.

Original languageEnglish
Pages (from-to)177-183
Number of pages7
JournalCanadian Journal of Psychiatry
Volume58
Issue number3
DOIs
StatePublished - Mar 2013
Externally publishedYes

Keywords

  • Attention-deficit hyperactivity disorder
  • Familial risk
  • Nicotine dependence
  • Smoking

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