Examining both sides of a Janus PTB domain

Kelley S. Yan, Ming Ming Zhou

Research output: Contribution to journalShort surveypeer-review

1 Scopus citations


The crystal structure of the Disabled-1 PTB domain in a ternary complex with the phosphoinositide PI-4,5P2 and an NPVY peptide of the apolipoprotein E receptor-2 reveals how this conserved scaffold simultaneously recognizes two distinct biological ligands required for signaling through this family of receptors.

Original languageEnglish
Pages (from-to)482-484
Number of pages3
Issue number5
StatePublished - 1 May 2003
Externally publishedYes


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