Ewing's sarcoma of the kidney

Joel R. Angel; Anushayanthan Alfred; Ankit Sakhuja; Ryan E. Sells; Joseph John Zechlinski

doi:10.1007/s10147-010-0042-0

Ewing's sarcoma of the kidney

Joel R. Angel
, Anushayanthan Alfred
, Ankit Sakhuja
, Ryan E. Sells
, Joseph John Zechlinski

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Primitive neuroectodermal tumors (PNETs) are small, round-cell tumors of neural crest origin classically found in the central nervous system (CNS) but more recently characterized in the periphery. Peripherally located PNETs (pPNETs) are members of the Ewing's sarcoma family of tumors (EFTs). Renal localization of pPNETs is very rare, is found in young adults, and is characterized by an aggressive clinical course and poor prognosis. We present the case of a young man with renal pPNET characterized by psuedorosette formation, cluster of differentiation 99 (CD 99?), focally positive for neuron-specific enolase (NSE), with cytogenetic findings of the translocation t(11;22)(q24;q12) and the unique abnormality of trisomy 7. To our knowledge, we report the first case of trisomy 7 and PNET.

Original language	English
Pages (from-to)	314-318
Number of pages	5
Journal	International Journal of Clinical Oncology
Volume	15
Issue number	3
DOIs	https://doi.org/10.1007/s10147-010-0042-0
State	Published - Jun 2010
Externally published	Yes

Keywords

Ewing's sarcoma
Primitive neuroectodermal tumor
Translocation
Trisomy

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10.1007/s10147-010-0042-0

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title = "Ewing's sarcoma of the kidney",

abstract = "Primitive neuroectodermal tumors (PNETs) are small, round-cell tumors of neural crest origin classically found in the central nervous system (CNS) but more recently characterized in the periphery. Peripherally located PNETs (pPNETs) are members of the Ewing's sarcoma family of tumors (EFTs). Renal localization of pPNETs is very rare, is found in young adults, and is characterized by an aggressive clinical course and poor prognosis. We present the case of a young man with renal pPNET characterized by psuedorosette formation, cluster of differentiation 99 (CD 99?), focally positive for neuron-specific enolase (NSE), with cytogenetic findings of the translocation t(11;22)(q24;q12) and the unique abnormality of trisomy 7. To our knowledge, we report the first case of trisomy 7 and PNET.",

keywords = "Ewing's sarcoma, Primitive neuroectodermal tumor, Translocation, Trisomy",

author = "Angel, \{Joel R.\} and Anushayanthan Alfred and Ankit Sakhuja and Sells, \{Ryan E.\} and Zechlinski, \{Joseph John\}",

year = "2010",

month = jun,

doi = "10.1007/s10147-010-0042-0",

language = "English",

volume = "15",

pages = "314--318",

journal = "International Journal of Clinical Oncology",

issn = "1341-9625",

publisher = "Springer",

number = "3",

}

TY - JOUR

T1 - Ewing's sarcoma of the kidney

AU - Angel, Joel R.

AU - Alfred, Anushayanthan

AU - Sakhuja, Ankit

AU - Sells, Ryan E.

AU - Zechlinski, Joseph John

PY - 2010/6

Y1 - 2010/6

N2 - Primitive neuroectodermal tumors (PNETs) are small, round-cell tumors of neural crest origin classically found in the central nervous system (CNS) but more recently characterized in the periphery. Peripherally located PNETs (pPNETs) are members of the Ewing's sarcoma family of tumors (EFTs). Renal localization of pPNETs is very rare, is found in young adults, and is characterized by an aggressive clinical course and poor prognosis. We present the case of a young man with renal pPNET characterized by psuedorosette formation, cluster of differentiation 99 (CD 99?), focally positive for neuron-specific enolase (NSE), with cytogenetic findings of the translocation t(11;22)(q24;q12) and the unique abnormality of trisomy 7. To our knowledge, we report the first case of trisomy 7 and PNET.

AB - Primitive neuroectodermal tumors (PNETs) are small, round-cell tumors of neural crest origin classically found in the central nervous system (CNS) but more recently characterized in the periphery. Peripherally located PNETs (pPNETs) are members of the Ewing's sarcoma family of tumors (EFTs). Renal localization of pPNETs is very rare, is found in young adults, and is characterized by an aggressive clinical course and poor prognosis. We present the case of a young man with renal pPNET characterized by psuedorosette formation, cluster of differentiation 99 (CD 99?), focally positive for neuron-specific enolase (NSE), with cytogenetic findings of the translocation t(11;22)(q24;q12) and the unique abnormality of trisomy 7. To our knowledge, we report the first case of trisomy 7 and PNET.

KW - Ewing's sarcoma

KW - Primitive neuroectodermal tumor

KW - Translocation

KW - Trisomy

UR - https://www.scopus.com/pages/publications/77955714360

U2 - 10.1007/s10147-010-0042-0

DO - 10.1007/s10147-010-0042-0

M3 - Article

C2 - 20198399

AN - SCOPUS:77955714360

SN - 1341-9625

VL - 15

SP - 314

EP - 318

JO - International Journal of Clinical Oncology

JF - International Journal of Clinical Oncology

IS - 3

ER -

Ewing's sarcoma of the kidney

Abstract

Keywords

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