TY - JOUR
T1 - Evolutionary relationships between gag gene-coded proteins of murine and primate endogenous type C RNA viruses
AU - Barbacid, Mariano
AU - Stephenson, John R.
AU - Aaronson, Stuart A.
N1 - Funding Information:
The authors thank Candice A. Deren for excellent technical assistance. This research was supported in part by a contract from the Virus Cancer Program of the National Cancer Institute. M. B. is a visiting fellow of the NIH, on leave of absence from the lnstituto de Bioquimica de Macromoleculas. Madrid, Spain.
PY - 1977/4
Y1 - 1977/4
N2 - Several low molecular weight proteins of endogenous type C viruses of the RD114/baboon group are compared with the gag gene translational products of endogenous type C viruses of murine origin. The p10 proteins of each virus group are shown to be immunologically and biochemically related, while the p12 proteins of RD114/baboon viruses are demonstrated to share antigenic determinants with murine viral p15. Moreover, highly type-specific phosphoproteins, p15 of RD114/baboon viruses and p12 of murine viruses, are shown to possess very similar biochemical properties. These findings, along with previous studies indicating immunologic cross-reactivity between their major internal antigens, p30, demonstrate that each of the gag gene-coded proteins of murine type C viruses has an analogue in viruses of the RD114/baboon group. The immunologic and biochemical relatedness of their gag gene translational products supports the concept of a common progenitor in the evolution of these endogenous viruses.
AB - Several low molecular weight proteins of endogenous type C viruses of the RD114/baboon group are compared with the gag gene translational products of endogenous type C viruses of murine origin. The p10 proteins of each virus group are shown to be immunologically and biochemically related, while the p12 proteins of RD114/baboon viruses are demonstrated to share antigenic determinants with murine viral p15. Moreover, highly type-specific phosphoproteins, p15 of RD114/baboon viruses and p12 of murine viruses, are shown to possess very similar biochemical properties. These findings, along with previous studies indicating immunologic cross-reactivity between their major internal antigens, p30, demonstrate that each of the gag gene-coded proteins of murine type C viruses has an analogue in viruses of the RD114/baboon group. The immunologic and biochemical relatedness of their gag gene translational products supports the concept of a common progenitor in the evolution of these endogenous viruses.
UR - https://www.scopus.com/pages/publications/0017683682
U2 - 10.1016/0092-8674(77)90097-6
DO - 10.1016/0092-8674(77)90097-6
M3 - Article
C2 - 67898
AN - SCOPUS:0017683682
SN - 0092-8674
VL - 10
SP - 641
EP - 648
JO - Cell
JF - Cell
IS - 4
ER -