Evidence that the butyryl-cholinesterase K variant can protect against late-onset Alzheimer's disease

Simon M. Laws; Kevin Taddei; Christopher Fisher; David Small; Roger Clarnette; Joachim Hallmayer; William S. Brooks; John B.J. Kwok; Peter R. Schofield; Samuel E. Gandy; Ralph N. Martins

Evidence that the butyryl-cholinesterase K variant can protect against late-onset Alzheimer's disease

Simon M. Laws, Kevin Taddei, Christopher Fisher, David Small, Roger Clarnette, Joachim Hallmayer, William S. Brooks, John B.J. Kwok, Peter R. Schofield, Samuel E. Gandy, Ralph N. Martins

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Recent reports indicate that the K variant of the butyrylcholinesterase (BCHE-K) gene may, in some situations, act in synergism with the ε4 allele of apolipoprotein E (ApoE ε4) to increase the risk of Alzheimer's Disease (AD). Determination of the frequency of the BCHE-K genotype in a sample of 237 AD and 347 control cases did not support an association of BCHE-K with an increased risk of AD but, instead suggested a possible protective effect of BCHE-K. Further epidemiological and biological assessment of these subsets will be required in order to confirm this observation and elucidate the pathophysiological role of BCHE-K in AD.

Original language	English
Pages (from-to)	219-223
Number of pages	5
Journal	Alzheimer's Reports
Volume	2
Issue number	4
State	Published - 1999
Externally published	Yes

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title = "Evidence that the butyryl-cholinesterase K variant can protect against late-onset Alzheimer's disease",

abstract = "Recent reports indicate that the K variant of the butyrylcholinesterase (BCHE-K) gene may, in some situations, act in synergism with the ε4 allele of apolipoprotein E (ApoE ε4) to increase the risk of Alzheimer's Disease (AD). Determination of the frequency of the BCHE-K genotype in a sample of 237 AD and 347 control cases did not support an association of BCHE-K with an increased risk of AD but, instead suggested a possible protective effect of BCHE-K. Further epidemiological and biological assessment of these subsets will be required in order to confirm this observation and elucidate the pathophysiological role of BCHE-K in AD.",

author = "Laws, {Simon M.} and Kevin Taddei and Christopher Fisher and David Small and Roger Clarnette and Joachim Hallmayer and Brooks, {William S.} and Kwok, {John B.J.} and Schofield, {Peter R.} and Gandy, {Samuel E.} and Martins, {Ralph N.}",

year = "1999",

language = "English",

volume = "2",

pages = "219--223",

journal = "Alzheimer's Reports",

issn = "1461-6130",

publisher = "Cardiff University",

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T1 - Evidence that the butyryl-cholinesterase K variant can protect against late-onset Alzheimer's disease

AU - Laws, Simon M.

AU - Taddei, Kevin

AU - Fisher, Christopher

AU - Small, David

AU - Clarnette, Roger

AU - Hallmayer, Joachim

AU - Brooks, William S.

AU - Kwok, John B.J.

AU - Schofield, Peter R.

AU - Gandy, Samuel E.

AU - Martins, Ralph N.

PY - 1999

Y1 - 1999

N2 - Recent reports indicate that the K variant of the butyrylcholinesterase (BCHE-K) gene may, in some situations, act in synergism with the ε4 allele of apolipoprotein E (ApoE ε4) to increase the risk of Alzheimer's Disease (AD). Determination of the frequency of the BCHE-K genotype in a sample of 237 AD and 347 control cases did not support an association of BCHE-K with an increased risk of AD but, instead suggested a possible protective effect of BCHE-K. Further epidemiological and biological assessment of these subsets will be required in order to confirm this observation and elucidate the pathophysiological role of BCHE-K in AD.

AB - Recent reports indicate that the K variant of the butyrylcholinesterase (BCHE-K) gene may, in some situations, act in synergism with the ε4 allele of apolipoprotein E (ApoE ε4) to increase the risk of Alzheimer's Disease (AD). Determination of the frequency of the BCHE-K genotype in a sample of 237 AD and 347 control cases did not support an association of BCHE-K with an increased risk of AD but, instead suggested a possible protective effect of BCHE-K. Further epidemiological and biological assessment of these subsets will be required in order to confirm this observation and elucidate the pathophysiological role of BCHE-K in AD.

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M3 - Article

AN - SCOPUS:0043119645

SN - 1461-6130

VL - 2

SP - 219

EP - 223

JO - Alzheimer's Reports

JF - Alzheimer's Reports

IS - 4

ER -

Evidence that the butyryl-cholinesterase K variant can protect against late-onset Alzheimer's disease

Abstract

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