Evidence that Ginkgo biloba extract does not inhibit MAO A and B in living human brain

Joanna S. Fowler; G. J. Wang; N. D. Volkow; J. Logan; D. Franceschi; M. Franceschi; R. MacGregor; C. Shea; V. Garza; N. Liu; Y. S. Ding

doi:10.1016/s0024-3205(99)00660-8

Evidence that Ginkgo biloba extract does not inhibit MAO A and B in living human brain

Joanna S. Fowler, G. J. Wang, N. D. Volkow, J. Logan, D. Franceschi, M. Franceschi, R. MacGregor, C. Shea, V. Garza, N. Liu, Y. S. Ding

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28 Scopus citations

Abstract

Extracts of Ginkgo biloba have been reported to reversibly inhibit both monoamine oxidase (MAO) A and B in rat brain in vitro leading to speculation that MAO inhibition may contribute to some of its central nervous system effects. Here we have used positron emission tomography (PET) to measure the effects of Ginkgo biloba on human brain MAO A and B in 10 subjects treated for 1 month with 120 mg/day of the Ginkgo biloba extract EGb 761, using [¹¹C]clorgyline and [¹¹C]L-deprenyl-D2 to measure MAO A and B respectively. A three-compartment model was used to calculate the plasma to brain transfer constant K₁ which is related to blood flow, and λk₃, a model term which is a function of the concentration of catalytically active MAO molecules. Ginkgo biloba administration did not produce significant changes in brain MAO A or MAO B suggesting that mechanisms other than MAO inhibition need to be considered as mediating some of its CNS effects. (C) 2000 Elsevier Science Inc.

Original language	English
Pages (from-to)	PL141-PL146
Journal	Life Sciences
Volume	66
Issue number	9
DOIs	https://doi.org/10.1016/s0024-3205(99)00660-8
State	Published - 21 Jan 2000
Externally published	Yes

Keywords

Egb 761
Ginkgo biloba
MAO A
MAO B
PET

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10.1016/s0024-3205(99)00660-8

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title = "Evidence that Ginkgo biloba extract does not inhibit MAO A and B in living human brain",

abstract = "Extracts of Ginkgo biloba have been reported to reversibly inhibit both monoamine oxidase (MAO) A and B in rat brain in vitro leading to speculation that MAO inhibition may contribute to some of its central nervous system effects. Here we have used positron emission tomography (PET) to measure the effects of Ginkgo biloba on human brain MAO A and B in 10 subjects treated for 1 month with 120 mg/day of the Ginkgo biloba extract EGb 761, using [11C]clorgyline and [11C]L-deprenyl-D2 to measure MAO A and B respectively. A three-compartment model was used to calculate the plasma to brain transfer constant K1 which is related to blood flow, and λk3, a model term which is a function of the concentration of catalytically active MAO molecules. Ginkgo biloba administration did not produce significant changes in brain MAO A or MAO B suggesting that mechanisms other than MAO inhibition need to be considered as mediating some of its CNS effects. (C) 2000 Elsevier Science Inc.",

keywords = "Egb 761, Ginkgo biloba, MAO A, MAO B, PET",

author = "Fowler, {Joanna S.} and Wang, {G. J.} and Volkow, {N. D.} and J. Logan and D. Franceschi and M. Franceschi and R. MacGregor and C. Shea and V. Garza and N. Liu and Ding, {Y. S.}",

note = "Funding Information: This researchw as carried out at Brookhaven National Laboratory under contract DE-ACOZ-98CH10886 and with the U. S. Departmento f Energy and supportedb y its Office of Biological and Environmental Researcha nd also by the National Institutes of Health grant NS 1.5380 The authors are grateful to Noel Netusil, Pauline Carter, Richard Ferrieri, Robert Carciello, Donald Warner and David Schlyer for advice and assistancea nd to Lois Caligiuri for organization and administration.",

year = "2000",

month = jan,

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doi = "10.1016/s0024-3205(99)00660-8",

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T1 - Evidence that Ginkgo biloba extract does not inhibit MAO A and B in living human brain

AU - Fowler, Joanna S.

AU - Wang, G. J.

AU - Volkow, N. D.

AU - Logan, J.

AU - Franceschi, D.

AU - Franceschi, M.

AU - MacGregor, R.

AU - Shea, C.

AU - Garza, V.

AU - Liu, N.

AU - Ding, Y. S.

N1 - Funding Information: This researchw as carried out at Brookhaven National Laboratory under contract DE-ACOZ-98CH10886 and with the U. S. Departmento f Energy and supportedb y its Office of Biological and Environmental Researcha nd also by the National Institutes of Health grant NS 1.5380 The authors are grateful to Noel Netusil, Pauline Carter, Richard Ferrieri, Robert Carciello, Donald Warner and David Schlyer for advice and assistancea nd to Lois Caligiuri for organization and administration.

PY - 2000/1/21

Y1 - 2000/1/21

N2 - Extracts of Ginkgo biloba have been reported to reversibly inhibit both monoamine oxidase (MAO) A and B in rat brain in vitro leading to speculation that MAO inhibition may contribute to some of its central nervous system effects. Here we have used positron emission tomography (PET) to measure the effects of Ginkgo biloba on human brain MAO A and B in 10 subjects treated for 1 month with 120 mg/day of the Ginkgo biloba extract EGb 761, using [11C]clorgyline and [11C]L-deprenyl-D2 to measure MAO A and B respectively. A three-compartment model was used to calculate the plasma to brain transfer constant K1 which is related to blood flow, and λk3, a model term which is a function of the concentration of catalytically active MAO molecules. Ginkgo biloba administration did not produce significant changes in brain MAO A or MAO B suggesting that mechanisms other than MAO inhibition need to be considered as mediating some of its CNS effects. (C) 2000 Elsevier Science Inc.

AB - Extracts of Ginkgo biloba have been reported to reversibly inhibit both monoamine oxidase (MAO) A and B in rat brain in vitro leading to speculation that MAO inhibition may contribute to some of its central nervous system effects. Here we have used positron emission tomography (PET) to measure the effects of Ginkgo biloba on human brain MAO A and B in 10 subjects treated for 1 month with 120 mg/day of the Ginkgo biloba extract EGb 761, using [11C]clorgyline and [11C]L-deprenyl-D2 to measure MAO A and B respectively. A three-compartment model was used to calculate the plasma to brain transfer constant K1 which is related to blood flow, and λk3, a model term which is a function of the concentration of catalytically active MAO molecules. Ginkgo biloba administration did not produce significant changes in brain MAO A or MAO B suggesting that mechanisms other than MAO inhibition need to be considered as mediating some of its CNS effects. (C) 2000 Elsevier Science Inc.

KW - Egb 761

KW - Ginkgo biloba

KW - MAO A

KW - MAO B

KW - PET

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DO - 10.1016/s0024-3205(99)00660-8

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AN - SCOPUS:0034695279

SN - 0024-3205

VL - 66

SP - PL141-PL146

JO - Life Sciences

JF - Life Sciences

IS - 9

ER -

Evidence that Ginkgo biloba extract does not inhibit MAO A and B in living human brain

Abstract

Keywords

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