Evidence of lymphocyte alveolitis in Crohn's disease

B. Wallaert; J. F. Colombel; A. B. Tonnel; P. Bonniere; A. Cortot; J. C. Paris; C. Voisin

doi:10.1378/chest.87.3.363

Evidence of lymphocyte alveolitis in Crohn's disease

B. Wallaert, J. F. Colombel, A. B. Tonnel, P. Bonniere, A. Cortot, J. C. Paris, C. Voisin

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Abstract

Cellular characteristics of bronchoalveolar lavage (BAL) were investigated in 18 consecutive patients with Crohn's disease, who were free of clinical pulmonary symptoms and had normal findings on chest roentgenograms. Total BAL cell count and cellular viability of alveolar macrophages did not differ significantly between patients and control subjects. Percentage of alveolar lymphocytes was increased in 11 of 18 patients (from 18 percent to 79 percent). There was no apparent correlation between BAL differential cell count and abnormal pulmonary function tests noted in 11 patients, drug treatment or Crohn's disease site, and activity. These results demonstrate a high proportion of latent lymphocyte alveolitis as assessed by BAL, suggesting a latent involvement of the lung in Crohn's disease.

Original language	English
Pages (from-to)	363-367
Number of pages	5
Journal	Chest
Volume	87
Issue number	3
DOIs	https://doi.org/10.1378/chest.87.3.363
State	Published - 1985
Externally published	Yes

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title = "Evidence of lymphocyte alveolitis in Crohn's disease",

abstract = "Cellular characteristics of bronchoalveolar lavage (BAL) were investigated in 18 consecutive patients with Crohn's disease, who were free of clinical pulmonary symptoms and had normal findings on chest roentgenograms. Total BAL cell count and cellular viability of alveolar macrophages did not differ significantly between patients and control subjects. Percentage of alveolar lymphocytes was increased in 11 of 18 patients (from 18 percent to 79 percent). There was no apparent correlation between BAL differential cell count and abnormal pulmonary function tests noted in 11 patients, drug treatment or Crohn's disease site, and activity. These results demonstrate a high proportion of latent lymphocyte alveolitis as assessed by BAL, suggesting a latent involvement of the lung in Crohn's disease.",

author = "B. Wallaert and Colombel, {J. F.} and Tonnel, {A. B.} and P. Bonniere and A. Cortot and Paris, {J. C.} and C. Voisin",

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T1 - Evidence of lymphocyte alveolitis in Crohn's disease

AU - Wallaert, B.

AU - Colombel, J. F.

AU - Tonnel, A. B.

AU - Bonniere, P.

AU - Cortot, A.

AU - Paris, J. C.

AU - Voisin, C.

N1 - Funding Information: Supported by University of Lille II.

PY - 1985

Y1 - 1985

N2 - Cellular characteristics of bronchoalveolar lavage (BAL) were investigated in 18 consecutive patients with Crohn's disease, who were free of clinical pulmonary symptoms and had normal findings on chest roentgenograms. Total BAL cell count and cellular viability of alveolar macrophages did not differ significantly between patients and control subjects. Percentage of alveolar lymphocytes was increased in 11 of 18 patients (from 18 percent to 79 percent). There was no apparent correlation between BAL differential cell count and abnormal pulmonary function tests noted in 11 patients, drug treatment or Crohn's disease site, and activity. These results demonstrate a high proportion of latent lymphocyte alveolitis as assessed by BAL, suggesting a latent involvement of the lung in Crohn's disease.

AB - Cellular characteristics of bronchoalveolar lavage (BAL) were investigated in 18 consecutive patients with Crohn's disease, who were free of clinical pulmonary symptoms and had normal findings on chest roentgenograms. Total BAL cell count and cellular viability of alveolar macrophages did not differ significantly between patients and control subjects. Percentage of alveolar lymphocytes was increased in 11 of 18 patients (from 18 percent to 79 percent). There was no apparent correlation between BAL differential cell count and abnormal pulmonary function tests noted in 11 patients, drug treatment or Crohn's disease site, and activity. These results demonstrate a high proportion of latent lymphocyte alveolitis as assessed by BAL, suggesting a latent involvement of the lung in Crohn's disease.

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DO - 10.1378/chest.87.3.363

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SN - 0012-3692

VL - 87

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JO - Chest

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Evidence of lymphocyte alveolitis in Crohn's disease

Abstract

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