Evidence for transmission disequilibrium at the DAOA gene locus in a schizophrenia family sample

Jie Ma; Jian Sun; Huan Zhang; Rui Zhang; Wan Hu Kang; Cheng Ge Gao; Hai Sheng Liu; Xue Hong Ma; Zi Xin Min; Wen Xiang Zhao; Qi Lan Ning; Shu Hong Wang; Yin Cang Zhang; Ting Wei Guo; She Min Lu

doi:10.1016/j.neulet.2009.06.070

Evidence for transmission disequilibrium at the DAOA gene locus in a schizophrenia family sample

Jie Ma
, Jian Sun
, Huan Zhang
, Rui Zhang
, Wan Hu Kang
, Cheng Ge Gao
, Hai Sheng Liu
, Xue Hong Ma
, Zi Xin Min
, Wen Xiang Zhao
, Qi Lan Ning
, Shu Hong Wang
, Yin Cang Zhang
, Ting Wei Guo
, She Min Lu

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Recently, the DAOA gene locus on chromosome 13q32-q34 has been implicated in the etiology of schizophrenia. We genotyped three single-nucleotide polymorphisms (SNPs: rs778294, rs779293 and rs3918342) in this region in 126 Chinese family trios. In this study, we have identified statistically significant transmission disequilibrium in two markers rs778293 (P = 0.01) and rs3918342 (P = 0.02), and a highly significant under-transmission between haplotype CAT (P = 0.0005) and schizophrenia. The results provide further evidence to support that DAOA gene locus is involved in conferring susceptibility to schizophrenia.

Original language	English
Pages (from-to)	105-108
Number of pages	4
Journal	Neuroscience Letters
Volume	462
Issue number	2
DOIs	https://doi.org/10.1016/j.neulet.2009.06.070
State	Published - 22 Sep 2009
Externally published	Yes

Keywords

Association
DAOA
Haplotype
SNP
Schizophrenia
TDT

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10.1016/j.neulet.2009.06.070

Cite this

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title = "Evidence for transmission disequilibrium at the DAOA gene locus in a schizophrenia family sample",

abstract = "Recently, the DAOA gene locus on chromosome 13q32-q34 has been implicated in the etiology of schizophrenia. We genotyped three single-nucleotide polymorphisms (SNPs: rs778294, rs779293 and rs3918342) in this region in 126 Chinese family trios. In this study, we have identified statistically significant transmission disequilibrium in two markers rs778293 (P = 0.01) and rs3918342 (P = 0.02), and a highly significant under-transmission between haplotype CAT (P = 0.0005) and schizophrenia. The results provide further evidence to support that DAOA gene locus is involved in conferring susceptibility to schizophrenia.",

keywords = "Association, DAOA, Haplotype, SNP, Schizophrenia, TDT",

author = "Jie Ma and Jian Sun and Huan Zhang and Rui Zhang and Kang, \{Wan Hu\} and Gao, \{Cheng Ge\} and Liu, \{Hai Sheng\} and Ma, \{Xue Hong\} and Min, \{Zi Xin\} and Zhao, \{Wen Xiang\} and Ning, \{Qi Lan\} and Wang, \{Shu Hong\} and Zhang, \{Yin Cang\} and Guo, \{Ting Wei\} and Lu, \{She Min\}",

year = "2009",

month = sep,

day = "22",

doi = "10.1016/j.neulet.2009.06.070",

language = "English",

volume = "462",

pages = "105--108",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

number = "2",

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TY - JOUR

T1 - Evidence for transmission disequilibrium at the DAOA gene locus in a schizophrenia family sample

AU - Ma, Jie

AU - Sun, Jian

AU - Zhang, Huan

AU - Zhang, Rui

AU - Kang, Wan Hu

AU - Gao, Cheng Ge

AU - Liu, Hai Sheng

AU - Ma, Xue Hong

AU - Min, Zi Xin

AU - Zhao, Wen Xiang

AU - Ning, Qi Lan

AU - Wang, Shu Hong

AU - Zhang, Yin Cang

AU - Guo, Ting Wei

AU - Lu, She Min

PY - 2009/9/22

Y1 - 2009/9/22

N2 - Recently, the DAOA gene locus on chromosome 13q32-q34 has been implicated in the etiology of schizophrenia. We genotyped three single-nucleotide polymorphisms (SNPs: rs778294, rs779293 and rs3918342) in this region in 126 Chinese family trios. In this study, we have identified statistically significant transmission disequilibrium in two markers rs778293 (P = 0.01) and rs3918342 (P = 0.02), and a highly significant under-transmission between haplotype CAT (P = 0.0005) and schizophrenia. The results provide further evidence to support that DAOA gene locus is involved in conferring susceptibility to schizophrenia.

AB - Recently, the DAOA gene locus on chromosome 13q32-q34 has been implicated in the etiology of schizophrenia. We genotyped three single-nucleotide polymorphisms (SNPs: rs778294, rs779293 and rs3918342) in this region in 126 Chinese family trios. In this study, we have identified statistically significant transmission disequilibrium in two markers rs778293 (P = 0.01) and rs3918342 (P = 0.02), and a highly significant under-transmission between haplotype CAT (P = 0.0005) and schizophrenia. The results provide further evidence to support that DAOA gene locus is involved in conferring susceptibility to schizophrenia.

KW - Association

KW - DAOA

KW - Haplotype

KW - SNP

KW - Schizophrenia

KW - TDT

UR - https://www.scopus.com/pages/publications/67650963683

U2 - 10.1016/j.neulet.2009.06.070

DO - 10.1016/j.neulet.2009.06.070

M3 - Article

C2 - 19560517

AN - SCOPUS:67650963683

SN - 0304-3940

VL - 462

SP - 105

EP - 108

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 2

ER -

Evidence for transmission disequilibrium at the DAOA gene locus in a schizophrenia family sample

Abstract

Keywords

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