Evidence for the presence of antibodies to cholinergic neurons in the serum of patients with Alzheimer's disease

P. Foley; H. F. Bradford; M. Docherty; H. Fillit; V. N. Luine; B. McEwen; G. Bucht; B. Winblad; J. Hardy

doi:10.1007/BF00314249

Evidence for the presence of antibodies to cholinergic neurons in the serum of patients with Alzheimer's disease

P. Foley
, H. F. Bradford
, M. Docherty
, H. Fillit
, V. N. Luine
, B. McEwen
, G. Bucht
, B. Winblad
, J. Hardy

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

A blind study showing that serum from patients with Alzheimer's disease causes immunolysis of mammalian brain synaptosomes is reported. Control, aged-matched, sera were largely without effect. The immunolysis was directed mainly against cholinergic synaptosomes. The data presented support the hypothesis that autoimmune mechanisms may operate in the pathogenesis of Alzheimer's disease.

Original language	English
Pages (from-to)	466-471
Number of pages	6
Journal	Journal of Neurology
Volume	235
Issue number	8
DOIs	https://doi.org/10.1007/BF00314249
State	Published - Nov 1988
Externally published	Yes

Keywords

Alzheimer's disease
Cholinergic neurones
Immunolysis
Synaptosomes

Access to Document

10.1007/BF00314249

Cite this

@article{1e49709847344195845a90a5991fa8e8,

title = "Evidence for the presence of antibodies to cholinergic neurons in the serum of patients with Alzheimer's disease",

abstract = "A blind study showing that serum from patients with Alzheimer's disease causes immunolysis of mammalian brain synaptosomes is reported. Control, aged-matched, sera were largely without effect. The immunolysis was directed mainly against cholinergic synaptosomes. The data presented support the hypothesis that autoimmune mechanisms may operate in the pathogenesis of Alzheimer's disease.",

keywords = "Alzheimer's disease, Cholinergic neurones, Immunolysis, Synaptosomes",

author = "P. Foley and Bradford, \{H. F.\} and M. Docherty and H. Fillit and Luine, \{V. N.\} and B. McEwen and G. Bucht and B. Winblad and J. Hardy",

year = "1988",

month = nov,

doi = "10.1007/BF00314249",

language = "English",

volume = "235",

pages = "466--471",

journal = "Journal of Neurology",

issn = "0340-5354",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "8",

}

TY - JOUR

T1 - Evidence for the presence of antibodies to cholinergic neurons in the serum of patients with Alzheimer's disease

AU - Foley, P.

AU - Bradford, H. F.

AU - Docherty, M.

AU - Fillit, H.

AU - Luine, V. N.

AU - McEwen, B.

AU - Bucht, G.

AU - Winblad, B.

AU - Hardy, J.

PY - 1988/11

Y1 - 1988/11

N2 - A blind study showing that serum from patients with Alzheimer's disease causes immunolysis of mammalian brain synaptosomes is reported. Control, aged-matched, sera were largely without effect. The immunolysis was directed mainly against cholinergic synaptosomes. The data presented support the hypothesis that autoimmune mechanisms may operate in the pathogenesis of Alzheimer's disease.

AB - A blind study showing that serum from patients with Alzheimer's disease causes immunolysis of mammalian brain synaptosomes is reported. Control, aged-matched, sera were largely without effect. The immunolysis was directed mainly against cholinergic synaptosomes. The data presented support the hypothesis that autoimmune mechanisms may operate in the pathogenesis of Alzheimer's disease.

KW - Alzheimer's disease

KW - Cholinergic neurones

KW - Immunolysis

KW - Synaptosomes

UR - https://www.scopus.com/pages/publications/0023796433

U2 - 10.1007/BF00314249

DO - 10.1007/BF00314249

M3 - Article

C2 - 3210051

AN - SCOPUS:0023796433

SN - 0340-5354

VL - 235

SP - 466

EP - 471

JO - Journal of Neurology

JF - Journal of Neurology

IS - 8

ER -

Evidence for the presence of antibodies to cholinergic neurons in the serum of patients with Alzheimer's disease

Abstract

Keywords

Access to Document

Fingerprint

Cite this