TY - JOUR
T1 - Evidence for the clonal origin of acquired hypomegakaryocytic thrombocytopenic purpura from a sex chromosome mosaic
AU - Nieneltow, Marvin
AU - Cooper, Milton
AU - Breg, W. Roy
AU - Hoffman, Ronald
N1 - Funding Information:
Supported in part by NCI Grant CA22697 and NIH Grants AM28376, Dl1624, and HL07262. Dr. Hoffman is a recipient of a Research Career Development Award.
PY - 1984/7
Y1 - 1984/7
N2 - Cytogenetic studies performed on a 79-year-old female presenting with clinical and hematologic features of acquired hypomegakaryocytic thrombocytopenic purpura revealed sex chromosome mosaicism in blood lymphocytes (45,X/46,XX/47,XXX). The presence of only 45,X cells in the bone marrow is consistent with a unicellular origin of acquired hypomegakaryocytic thrombocytopenia in this patient. These studies also suggest that, in some instances, this disorder may originate at the level of the pluripotent hematopoietic stem cell.
AB - Cytogenetic studies performed on a 79-year-old female presenting with clinical and hematologic features of acquired hypomegakaryocytic thrombocytopenic purpura revealed sex chromosome mosaicism in blood lymphocytes (45,X/46,XX/47,XXX). The presence of only 45,X cells in the bone marrow is consistent with a unicellular origin of acquired hypomegakaryocytic thrombocytopenia in this patient. These studies also suggest that, in some instances, this disorder may originate at the level of the pluripotent hematopoietic stem cell.
UR - http://www.scopus.com/inward/record.url?scp=0021251315&partnerID=8YFLogxK
U2 - 10.1016/0165-4608(84)90038-4
DO - 10.1016/0165-4608(84)90038-4
M3 - Article
C2 - 6539163
AN - SCOPUS:0021251315
SN - 0165-4608
VL - 12
SP - 261
EP - 265
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 3
ER -