TY - JOUR
T1 - Evidence for the clonal nature of hypereosinophilic syndrome
AU - da Silva, Marco A.P.
AU - Heerema, Nyla
AU - Schwenk, Glenn R.
AU - Hoffman, Ronald
PY - 1988/5
Y1 - 1988/5
N2 - Hypereosinophilic syndrome (HES) is a disease process of unknown pathogenesis. Although some cases are believed to be primary hematologic malignancies, this issue remains unsolved. We present a case of HES in whom we have observed a clone of cytogenetically abnormal cells in the bone marrow in parallel with a clinical picture of a hematologic disorder characterized by progressive proliferation and organ infiltration by eosinophils. The cytogenetic abnormality 46,XY,t(7;12)(q11;p11) is previously unreported. Our case, plus other evidence present in the literature, supports the concept that HES is a hematologic malignant neoplasia.
AB - Hypereosinophilic syndrome (HES) is a disease process of unknown pathogenesis. Although some cases are believed to be primary hematologic malignancies, this issue remains unsolved. We present a case of HES in whom we have observed a clone of cytogenetically abnormal cells in the bone marrow in parallel with a clinical picture of a hematologic disorder characterized by progressive proliferation and organ infiltration by eosinophils. The cytogenetic abnormality 46,XY,t(7;12)(q11;p11) is previously unreported. Our case, plus other evidence present in the literature, supports the concept that HES is a hematologic malignant neoplasia.
UR - https://www.scopus.com/pages/publications/0023932665
U2 - 10.1016/0165-4608(88)90317-2
DO - 10.1016/0165-4608(88)90317-2
M3 - Article
C2 - 3355992
AN - SCOPUS:0023932665
SN - 0165-4608
VL - 32
SP - 109
EP - 115
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 1
ER -