@article{38ed6046b4134c4d88a4b1bfa7fa40d1,
title = "Evidence for linkage and association of GABRB3 and GABRA5 to panic disorder",
abstract = "Panic disorder (PD) is a debilitating anxiety disorder characterized by episodes of intense fear with autonomic and psychological symptoms that lead to behavioral impairment. A convergence of genetic and biological evidence implicates gamma-aminobutyric acid type A receptor subunits on chromosome 15q12 as candidate genes for PD. This study investigated 120 Caucasian, multiplex PD pedigrees using regional microsatellites (chr15q11-13) and found support for linkage (logarithm of odds (LOD) ≥2), with a prominent parent-of-origin effect. Genotyping with 10 single-nucleotide polymorphisms (SNPs) showed linkage to GABRB3 (rs11631421, LOD=4.6) and GABRA5 (rs2075716, LOD=2.2), and allelic association to GABRB3 (rs8024564, p=0.005; rs8025575, p=0.02) and GABRA5 (rs35399885, p=0.05). Genotyping of an independent Sardinian PD trio sample also supported association in the region, again with a parent-of-origin effect. These findings provide genetic evidence for the involvement of the genes GABRB3 and GABRA5 in the susceptibility to PD.",
author = "Hodges, {Laura M.} and Fyer, {Abby J.} and Weissman, {Myrna M.} and Logue, {Mark W.} and Fatemeh Haghighi and Oleg Evgrafov and Allessandro Rotondo and Knowles, {James A.} and Hamilton, {Steven P.}",
note = "Funding Information: This work was supported in part by an award from the Research Evaluation and Allocation Committee of the University of California, San Francisco (to SPH), NIMH Grants MH28274 (to MMW), MH37592 (to AJF), MH30906 (to Donald F Klein), MH48858 (to Susan E Hodge), HG002915 (to FH), MH074118 (to FH), and K01 MH076100 (to MWL). Dr Evgrafov declares that, except for income received from his primary employer and a one-time $400 payment from Illumina in 2013 for presentation of data at Illumina workshop, no financial support or compensation has been received from individual or corporate entity over the past 3 years for research or professional service, and there are no personal financial holdings that could be perceived as constituting a potential conflict of interest. Dr Knowles has received research support from the NIH, International OCD Foundation and Della Martin Foundation and speaker{\textquoteright}s honoraria from Illumina, Inc. Dr Weissman receives royalties from the Oxford University Press, Perseus Press, the American Psychiatric Association Press, and MultiHealth Systems. The remaining authors declare no conflict of interest.",
year = "2014",
month = sep,
doi = "10.1038/npp.2014.92",
language = "English",
volume = "39",
pages = "2423--2431",
journal = "Neuropsychopharmacology",
issn = "0893-133X",
publisher = "Nature Publishing Group",
number = "10",
}