Evidence for growth-promoting effects of Omega n - 3 fatty acids alone and in combination with a specific vitamin and mineral complex in rat neuroblastoma cells

Ravi Shrivastava, Bernard Vincent, Stephane Gobron, Nathalie Cucuat, Gareth W. John

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The beneficial effects of Omega n - 3 polyunsaturated fatty acids (n - 3 PUFA) in situations of cognitive impairment may be associated with enhanced neuronal growth. Since neuronal growth is impaired in n - 3 PUFA deficiency, and enhanced by certain vitamins and trace elements, the effects of n - 3 PUFA, vitamin and mineral cell complex (VMC) and their association on neuronal growth were investigated in cultured rat neuroblastoma cells. Treatment of cells for 3 days with n - 3 PUFA significantly enhanced neurite length without affecting the number of neurites or cells. VMC significantly increased cell number without affecting neurite length or their number. Combined n - 3 PUFA and VMC significantly enhanced all three growth parameters. The data confirm the growth promoting effects of n - 3 PUFA and VMC in cultured neurons over a relatively short time frame.

Original languageEnglish
Pages (from-to)317-321
Number of pages5
JournalNutritional Neuroscience
Volume8
Issue number5-6
DOIs
StatePublished - Oct 2005
Externally publishedYes

Keywords

  • Neuroblastoma cells
  • Neurodegeneration
  • Neuronal growth
  • Omega n - 3 polyunsaturated fatty acid
  • Vitamin and mineral cell complex

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