Evidence for genetic linkage Alzheimer's disease to chromosome 10q

L. Bertram; D. Blacker; K. Mullin; D. Keeney; J. Jones; S. Basu; S. Yhu; M. G. McInnis; R. C.P. Go; K. Vekrellis; D. J. Selkoe; A. J. Saunders; R. E. Tanzi

doi:10.1126/science.290.5500.2302

Evidence for genetic linkage Alzheimer's disease to chromosome 10q

L. Bertram, D. Blacker, K. Mullin, D. Keeney, J. Jones, S. Basu, S. Yhu, M. G. McInnis, R. C.P. Go, K. Vekrellis, D. J. Selkoe, A. J. Saunders, R. E. Tanzi

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465 Scopus citations

Abstract

Recent studies suggest that insulin-degrading enzyme (IDE) in neurons and microglia degrades Aβ, the principal component of β-amyloid and one of the neuropathological hallmarks of Alzheimer's disease (AD). We performed parametric and nonparametric linkage analyses of seven genetic markers on chromosome 10q, six of which map near the IDE gene, in 435 multiplex AD families. These analyses revealed significant evidence of linkage for adjacent markers (D10S1671, D10S583, D10S1710, and D10S566), which was most pronounced in late-onset families. Furthermore, we found evidence for allele-specific association between the putative disease locus and marker D10S583, which has recently been located within 195 kilobases of the IDE gene.

Original language	English
Pages (from-to)	2302-2303
Number of pages	2
Journal	Science
Volume	290
Issue number	5500
DOIs	https://doi.org/10.1126/science.290.5500.2302
State	Published - 22 Dec 2000
Externally published	Yes

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title = "Evidence for genetic linkage Alzheimer's disease to chromosome 10q",

abstract = "Recent studies suggest that insulin-degrading enzyme (IDE) in neurons and microglia degrades Aβ, the principal component of β-amyloid and one of the neuropathological hallmarks of Alzheimer's disease (AD). We performed parametric and nonparametric linkage analyses of seven genetic markers on chromosome 10q, six of which map near the IDE gene, in 435 multiplex AD families. These analyses revealed significant evidence of linkage for adjacent markers (D10S1671, D10S583, D10S1710, and D10S566), which was most pronounced in late-onset families. Furthermore, we found evidence for allele-specific association between the putative disease locus and marker D10S583, which has recently been located within 195 kilobases of the IDE gene.",

author = "L. Bertram and D. Blacker and K. Mullin and D. Keeney and J. Jones and S. Basu and S. Yhu and McInnis, {M. G.} and Go, {R. C.P.} and K. Vekrellis and Selkoe, {D. J.} and Saunders, {A. J.} and Tanzi, {R. E.}",

year = "2000",

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doi = "10.1126/science.290.5500.2302",

language = "English",

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publisher = "American Association for the Advancement of Science",

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TY - JOUR

T1 - Evidence for genetic linkage Alzheimer's disease to chromosome 10q

AU - Bertram, L.

AU - Blacker, D.

AU - Mullin, K.

AU - Keeney, D.

AU - Jones, J.

AU - Basu, S.

AU - Yhu, S.

AU - McInnis, M. G.

AU - Go, R. C.P.

AU - Vekrellis, K.

AU - Selkoe, D. J.

AU - Saunders, A. J.

AU - Tanzi, R. E.

PY - 2000/12/22

Y1 - 2000/12/22

N2 - Recent studies suggest that insulin-degrading enzyme (IDE) in neurons and microglia degrades Aβ, the principal component of β-amyloid and one of the neuropathological hallmarks of Alzheimer's disease (AD). We performed parametric and nonparametric linkage analyses of seven genetic markers on chromosome 10q, six of which map near the IDE gene, in 435 multiplex AD families. These analyses revealed significant evidence of linkage for adjacent markers (D10S1671, D10S583, D10S1710, and D10S566), which was most pronounced in late-onset families. Furthermore, we found evidence for allele-specific association between the putative disease locus and marker D10S583, which has recently been located within 195 kilobases of the IDE gene.

AB - Recent studies suggest that insulin-degrading enzyme (IDE) in neurons and microglia degrades Aβ, the principal component of β-amyloid and one of the neuropathological hallmarks of Alzheimer's disease (AD). We performed parametric and nonparametric linkage analyses of seven genetic markers on chromosome 10q, six of which map near the IDE gene, in 435 multiplex AD families. These analyses revealed significant evidence of linkage for adjacent markers (D10S1671, D10S583, D10S1710, and D10S566), which was most pronounced in late-onset families. Furthermore, we found evidence for allele-specific association between the putative disease locus and marker D10S583, which has recently been located within 195 kilobases of the IDE gene.

UR - http://www.scopus.com/inward/record.url?scp=0034704198&partnerID=8YFLogxK

U2 - 10.1126/science.290.5500.2302

DO - 10.1126/science.290.5500.2302

M3 - Article

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AN - SCOPUS:0034704198

SN - 0036-8075

VL - 290

SP - 2302

EP - 2303

JO - Science

JF - Science

IS - 5500

ER -

Evidence for genetic linkage Alzheimer's disease to chromosome 10q

Abstract

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