Evidence for antigenic distinctness of the Epstein-Barr virus-determined nuclear antigen and the herpesvirus papio-determined nuclear antigen

Shinsuke Ohno, Janos Luka, George Klein

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Previous serological evidence indicated that Epstein-Barr virus-determined nuclear antigen (EBNA) has cross reactive components with the herpesvirus papio-determined nuclear antigen (HUPNA) and, in addition, it has distinct components of its own, not present in HUPNA. In the present study, this hypothesis was studied by absorption experiments. Absorption of anti-EBNA-positive human sera with EBNA abolished both anti-EBNA and anti-HUPNA reactivity. Absorption with HUPNA removed all anti-HUPNA reactivity but did not reduce anti-EBNA to any detectable degree, thus confirming the hypothesis.

Original languageEnglish
Pages (from-to)325-329
Number of pages5
JournalCancer Letters
Volume6
Issue number6
DOIs
StatePublished - May 1979
Externally publishedYes

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