Evidence against association of the FE65 gene (APBB1) intron 13 polymorphism in Alzheimer's patients

Suzanne Y. Guénette; Lars Bertram; Adam Crystal; Benjamin Bakondi; Bradley T. Hyman; G. William Rebeck; Rudolph E. Tanzi; Deborah Blacker

doi:10.1016/S0304-3940(00)01607-4

Evidence against association of the FE65 gene (APBB1) intron 13 polymorphism in Alzheimer's patients

Suzanne Y. Guénette, Lars Bertram, Adam Crystal, Benjamin Bakondi, Bradley T. Hyman, G. William Rebeck, Rudolph E. Tanzi, Deborah Blacker

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

A genetic polymorphism in intron 13 of the FE65 gene (APBB1) was reported to be associated with Alzheimer's disease (AD). Our analyses of this polymorphism, both in a family-based or a case-control sample, fail to support the association between the FE65 intron 13 polymorphism and AD. We performed the sibship disequilibrium test (SDT, P = 0.77) and the sib transmission/disequilibrium test (Sib-TDT, P = 0.56) in a family-based study which included 526 subjects from 158 sibships. In addition, we compared the genotype and allele frequencies of this biallelic polymorphism in 311 AD patients to those of a control group consisting of 260 subjects and found no significant difference (χ², P = 0.847 and P = 0.586, respectively). Furthermore, our two-point linkage analysis in a family-based sample was in agreement with a genome wide scan for linkage to AD and showed no evidence for linkage to the short arm of chromosome 11 where the FE65 gene is located. We conclude that the association of the FE65 intron 13 polymorphism with AD, if any, is smaller than previously reported. (C) 2000 Elsevier Science Ireland Ltd.

Original language	English
Pages (from-to)	17-20
Number of pages	4
Journal	Neuroscience Letters
Volume	296
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3940(00)01607-4
State	Published - 15 Dec 2000
Externally published	Yes

Keywords

APBB1
Alzheimer's disease
Case control sample
FE65
Family-based association
Polymorphism

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10.1016/S0304-3940(00)01607-4

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title = "Evidence against association of the FE65 gene (APBB1) intron 13 polymorphism in Alzheimer's patients",

abstract = "A genetic polymorphism in intron 13 of the FE65 gene (APBB1) was reported to be associated with Alzheimer's disease (AD). Our analyses of this polymorphism, both in a family-based or a case-control sample, fail to support the association between the FE65 intron 13 polymorphism and AD. We performed the sibship disequilibrium test (SDT, P = 0.77) and the sib transmission/disequilibrium test (Sib-TDT, P = 0.56) in a family-based study which included 526 subjects from 158 sibships. In addition, we compared the genotype and allele frequencies of this biallelic polymorphism in 311 AD patients to those of a control group consisting of 260 subjects and found no significant difference (χ2, P = 0.847 and P = 0.586, respectively). Furthermore, our two-point linkage analysis in a family-based sample was in agreement with a genome wide scan for linkage to AD and showed no evidence for linkage to the short arm of chromosome 11 where the FE65 gene is located. We conclude that the association of the FE65 intron 13 polymorphism with AD, if any, is smaller than previously reported. (C) 2000 Elsevier Science Ireland Ltd.",

keywords = "APBB1, Alzheimer's disease, Case control sample, FE65, Family-based association, Polymorphism",

author = "Gu{\'e}nette, {Suzanne Y.} and Lars Bertram and Adam Crystal and Benjamin Bakondi and Hyman, {Bradley T.} and Rebeck, {G. William} and Tanzi, {Rudolph E.} and Deborah Blacker",

year = "2000",

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doi = "10.1016/S0304-3940(00)01607-4",

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T1 - Evidence against association of the FE65 gene (APBB1) intron 13 polymorphism in Alzheimer's patients

AU - Guénette, Suzanne Y.

AU - Bertram, Lars

AU - Crystal, Adam

AU - Bakondi, Benjamin

AU - Hyman, Bradley T.

AU - Rebeck, G. William

AU - Tanzi, Rudolph E.

AU - Blacker, Deborah

PY - 2000/12/15

Y1 - 2000/12/15

N2 - A genetic polymorphism in intron 13 of the FE65 gene (APBB1) was reported to be associated with Alzheimer's disease (AD). Our analyses of this polymorphism, both in a family-based or a case-control sample, fail to support the association between the FE65 intron 13 polymorphism and AD. We performed the sibship disequilibrium test (SDT, P = 0.77) and the sib transmission/disequilibrium test (Sib-TDT, P = 0.56) in a family-based study which included 526 subjects from 158 sibships. In addition, we compared the genotype and allele frequencies of this biallelic polymorphism in 311 AD patients to those of a control group consisting of 260 subjects and found no significant difference (χ2, P = 0.847 and P = 0.586, respectively). Furthermore, our two-point linkage analysis in a family-based sample was in agreement with a genome wide scan for linkage to AD and showed no evidence for linkage to the short arm of chromosome 11 where the FE65 gene is located. We conclude that the association of the FE65 intron 13 polymorphism with AD, if any, is smaller than previously reported. (C) 2000 Elsevier Science Ireland Ltd.

AB - A genetic polymorphism in intron 13 of the FE65 gene (APBB1) was reported to be associated with Alzheimer's disease (AD). Our analyses of this polymorphism, both in a family-based or a case-control sample, fail to support the association between the FE65 intron 13 polymorphism and AD. We performed the sibship disequilibrium test (SDT, P = 0.77) and the sib transmission/disequilibrium test (Sib-TDT, P = 0.56) in a family-based study which included 526 subjects from 158 sibships. In addition, we compared the genotype and allele frequencies of this biallelic polymorphism in 311 AD patients to those of a control group consisting of 260 subjects and found no significant difference (χ2, P = 0.847 and P = 0.586, respectively). Furthermore, our two-point linkage analysis in a family-based sample was in agreement with a genome wide scan for linkage to AD and showed no evidence for linkage to the short arm of chromosome 11 where the FE65 gene is located. We conclude that the association of the FE65 intron 13 polymorphism with AD, if any, is smaller than previously reported. (C) 2000 Elsevier Science Ireland Ltd.

KW - APBB1

KW - Alzheimer's disease

KW - Case control sample

KW - FE65

KW - Family-based association

KW - Polymorphism

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Evidence against association of the FE65 gene (APBB1) intron 13 polymorphism in Alzheimer's patients

Abstract

Keywords

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