Events at the transition between cell cycle exit and oligodendrocyte progenitor differentiation: The role of HDAC and YY1

Ye He, Juan Sandoval, Patrizia Casaccia-Bonnefil

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

The complexity of the adult brain is the result of an integrated series of developmental events that depends on appropriate timing of differentiation. The importance of transcriptional regulatory networks and epigenetic mechanisms of regulation of gene expression is becoming increasingly evident. Among these mechanisms, previous work has revealed the importance of histone deacetylation in oligodendrocyte differentiation. In this manuscript we define the region of interaction between transcription factor Yin-Yang 1 (YY1) and histone deacetylase 1, and characterize the functional consequences of YY1 overexpression on the differentiation of oligodendrocyte progenitors.

Original languageEnglish
Pages (from-to)221-231
Number of pages11
JournalNeuron Glia Biology
Volume3
Issue number3
DOIs
StatePublished - Aug 2007
Externally publishedYes

Keywords

  • Brain
  • Chromatin
  • Development
  • Epigenetics
  • Myelin
  • Transcription

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