TY - JOUR
T1 - Event-related potentials in drug-naïve pediatric patients with obsessive-compulsive disorder
AU - Yamamuro, Kazuhiko
AU - Ota, Toyosaku
AU - Nakanishi, Yoko
AU - Matsuura, Hiroki
AU - Okazaki, Kosuke
AU - Kishimoto, Naoko
AU - Takahashi, Hiroyuki
AU - Iwasaka, Hidemi
AU - Iida, Junzo
AU - Kishimoto, Toshifumi
N1 - Publisher Copyright:
© 2015 Elsevier Ireland Ltd.
PY - 2015/12/15
Y1 - 2015/12/15
N2 - Obsessive-compulsive disorder (OCD) is one of the most common mental health disorders, characterized by obsessive thoughts and/or compulsive behaviors, which may involve specific disorders in cognition and/or information processing. Event-related potentials (ERPs) are commonly used as physiological measures of cognitive function as they are easily measured and noninvasive. In the present study, 20 drug-naïve pediatric patients with OCD were compared with 20 healthy control participants who were age- and sex-matched to perform the ERP. Based on the guidelines for evoked potential measurement, the P300 and mismatch negativity (MMN) were obtained by auditory odd-ball tasks. We found that the amplitudes of the P300 components in the Fz, Cz, Pz, C3, and C4 regions were significantly smaller in the OCD group compared with the control group. There were no between-group differences in P300 latency, MMN amplitude, or MMN latency. Moreover, we found significant correlations between scores on the Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS) and P300 amplitudes at Cz, Pz, and C3. The present study is the first to report smaller P300s and the associations between P300 abnormalities and CY-BOCS scores.
AB - Obsessive-compulsive disorder (OCD) is one of the most common mental health disorders, characterized by obsessive thoughts and/or compulsive behaviors, which may involve specific disorders in cognition and/or information processing. Event-related potentials (ERPs) are commonly used as physiological measures of cognitive function as they are easily measured and noninvasive. In the present study, 20 drug-naïve pediatric patients with OCD were compared with 20 healthy control participants who were age- and sex-matched to perform the ERP. Based on the guidelines for evoked potential measurement, the P300 and mismatch negativity (MMN) were obtained by auditory odd-ball tasks. We found that the amplitudes of the P300 components in the Fz, Cz, Pz, C3, and C4 regions were significantly smaller in the OCD group compared with the control group. There were no between-group differences in P300 latency, MMN amplitude, or MMN latency. Moreover, we found significant correlations between scores on the Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS) and P300 amplitudes at Cz, Pz, and C3. The present study is the first to report smaller P300s and the associations between P300 abnormalities and CY-BOCS scores.
KW - Event related potentials
KW - Mismatch negativity
KW - Obsessive-compulsive disorder
KW - P300
UR - http://www.scopus.com/inward/record.url?scp=84945327888&partnerID=8YFLogxK
U2 - 10.1016/j.psychres.2015.09.026
DO - 10.1016/j.psychres.2015.09.026
M3 - Article
C2 - 26410771
AN - SCOPUS:84945327888
SN - 0165-1781
VL - 230
SP - 394
EP - 399
JO - Psychiatry Research
JF - Psychiatry Research
IS - 2
ER -