Event-related potentials in drug-naïve pediatric patients with obsessive-compulsive disorder

Kazuhiko Yamamuro, Toyosaku Ota, Yoko Nakanishi, Hiroki Matsuura, Kosuke Okazaki, Naoko Kishimoto, Hiroyuki Takahashi, Hidemi Iwasaka, Junzo Iida, Toshifumi Kishimoto

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Obsessive-compulsive disorder (OCD) is one of the most common mental health disorders, characterized by obsessive thoughts and/or compulsive behaviors, which may involve specific disorders in cognition and/or information processing. Event-related potentials (ERPs) are commonly used as physiological measures of cognitive function as they are easily measured and noninvasive. In the present study, 20 drug-naïve pediatric patients with OCD were compared with 20 healthy control participants who were age- and sex-matched to perform the ERP. Based on the guidelines for evoked potential measurement, the P300 and mismatch negativity (MMN) were obtained by auditory odd-ball tasks. We found that the amplitudes of the P300 components in the Fz, Cz, Pz, C3, and C4 regions were significantly smaller in the OCD group compared with the control group. There were no between-group differences in P300 latency, MMN amplitude, or MMN latency. Moreover, we found significant correlations between scores on the Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS) and P300 amplitudes at Cz, Pz, and C3. The present study is the first to report smaller P300s and the associations between P300 abnormalities and CY-BOCS scores.

Original languageEnglish
Pages (from-to)394-399
Number of pages6
JournalPsychiatry Research
Volume230
Issue number2
DOIs
StatePublished - 15 Dec 2015
Externally publishedYes

Keywords

  • Event related potentials
  • Mismatch negativity
  • Obsessive-compulsive disorder
  • P300

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