TY - JOUR
T1 - Even “WISE-R?”—an Update on the NHLBI-Sponsored Women’s Ischemia Syndrome Evaluation
AU - Barsky, Lili
AU - Merz, C. Noel Bairey
AU - Wei, Janet
AU - Shufelt, Chrisandra
AU - Handberg, Eileen
AU - Pepine, Carl
AU - Rutledge, Thomas
AU - Reis, Steven
AU - Doyle, Mark
AU - Rogers, William
AU - Shaw, Leslee
AU - Sopko, George
N1 - Publisher Copyright:
© 2020, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2020/8/1
Y1 - 2020/8/1
N2 - Purpose of Review: For over 20 years, the Women’s Ischemia Syndrome Evaluation (WISE), a program sponsored by the National Heart, Lung, and Blood Institute, has explored diverse and important aspects of ischemic heart disease in women. Recent Findings: Women with symptoms and signs of ischemia but no significant epicardial obstructive coronary artery disease (INOCA) were documented to be at elevated risk for recurrent angina hospitalization, major adverse cardiac events, death, and health resource consumption rivaling those with obstructive coronary disease. Summary: WISE investigators have advanced our understanding of cardiovascular outcomes, systemic manifestations, psychological variables, socioeconomic factors, genetic contributions, hormonal status, advanced imaging, coronary functional findings, biomarkers, patient-reported outcomes, and treatments pertaining to women with this disease entity. This review delves into the WISE findings subsequent to a prior review1, postulates directions for future research, and asks are we “Even ‘WISE-R?’”.
AB - Purpose of Review: For over 20 years, the Women’s Ischemia Syndrome Evaluation (WISE), a program sponsored by the National Heart, Lung, and Blood Institute, has explored diverse and important aspects of ischemic heart disease in women. Recent Findings: Women with symptoms and signs of ischemia but no significant epicardial obstructive coronary artery disease (INOCA) were documented to be at elevated risk for recurrent angina hospitalization, major adverse cardiac events, death, and health resource consumption rivaling those with obstructive coronary disease. Summary: WISE investigators have advanced our understanding of cardiovascular outcomes, systemic manifestations, psychological variables, socioeconomic factors, genetic contributions, hormonal status, advanced imaging, coronary functional findings, biomarkers, patient-reported outcomes, and treatments pertaining to women with this disease entity. This review delves into the WISE findings subsequent to a prior review1, postulates directions for future research, and asks are we “Even ‘WISE-R?’”.
KW - Coronary microvascular dysfunction
KW - Ischemic heart disease
KW - NHLBI
KW - Non-obstructive coronary artery disease
KW - WISE
UR - http://www.scopus.com/inward/record.url?scp=85086722734&partnerID=8YFLogxK
U2 - 10.1007/s11883-020-00852-w
DO - 10.1007/s11883-020-00852-w
M3 - Review article
C2 - 32556630
AN - SCOPUS:85086722734
SN - 1523-3804
VL - 22
JO - Current Atherosclerosis Reports
JF - Current Atherosclerosis Reports
IS - 8
M1 - 35
ER -