Evaluation of the Vasodilator vs Inotropic Effect of Milrinone Using an Animal Model of Left Ventricular Failure: Reversal of Disopyramide Depression of the Myocardium with Milrinone

Emanuel Goldberg, Russell Berdoff, George Spivack, Azriel Haimowitz, Steven Tay

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Milrinone M has been shown to improve left ventricular LV performance in animal and human studies. M has strong vasodilator action, and whether increased LV performance is due primarily to vasodilation or to a direct positive inotropic effect is unclear. Ten mongrel dogs were studied. Disopyramide caused a significant and sus tained decrease in LV function and was a good model for myocardial depres sion. At equal reduction in systemic vascular resistance SVR, M reversed this LV depression to a significantly greater degree than nitroprusside NP did. At equal levels of vasodilation, M produced significantly greater improve ment in indices of LV function than NP did in our model of disopyramide- induced LV failure. This suggests that its effect on LV function is not due entirely to afterload reduction, or to reflex sympathetic stimulation, but has a substantial component of direct inotropic stimulation. This study also demon strated a reversal of disopyramide-induced LV dysfunction by M, which may be clinically useful since, as in many antiarrhythmics, myocardial depression may be a limiting factor in its use.

Original languageEnglish
Pages (from-to)657-662
Number of pages6
JournalAngiology
Volume38
Issue number9
DOIs
StatePublished - Sep 1987
Externally publishedYes

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