Evaluation of the efficacy of two carbamates, physostigmine and pyridostigmine, when used in conjunction for protection against organophosphate exposure

Richard P. Solana, Chris Gennings, Walter H. Carter, Dana Anderson, Willard J. Lennox, Richard A. Carchman, Larrel W. Harris

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Evaluation of the Efficacy of Two Carbamates, Physostigmine and Pyridostigmine, When Used in Conjunction for Protection against Organophosphate Exposure. SOLANA, R. P., GENNINGS, C., CARTER, W. H., JR., ANDERSON, D., LENNOX, W.J., CARCHMAN, R. A., AND HARRIS, L. W. (1990). Fundam. Appl Toxicol. 15, 814-819. Recent studies have shown that pretreatment with either pyridostigmine (PYR) or physostigmine (PHY) followed by atropine-oxime therapy is very effective in reducing the lethality of nerve agents. The therapeutic efficacy of a PHY and PYR combination pretreatment was evaluated in Guinea pigs challenged with two LD50s of soman. Endpoints measured were percentage of acetylcholinesterase inhibition induced by the pretreatment and survival up to 24 hr postchallenge. Response surface methodology was employed to describe the relationship between each endpoint and the pretreatment combination. Although both carbamates contributed to blood acetylcholinesterase inhibition, PHY alone protected as well as the optimal dose of the combination.

Original languageEnglish
Pages (from-to)814-819
Number of pages6
JournalToxicological Sciences
Volume15
Issue number4
DOIs
StatePublished - Nov 1990
Externally publishedYes

Fingerprint

Dive into the research topics of 'Evaluation of the efficacy of two carbamates, physostigmine and pyridostigmine, when used in conjunction for protection against organophosphate exposure'. Together they form a unique fingerprint.

Cite this