Evaluation of point-of-care International Normalized Ratio in sickle cell disease

Syeda Rahman, Andrew Srisuwananukorn, Robert E. Molokie, Michel Gowhari, Franklin Njoku, Faiz Ahmed Hussain, James Lee, Edith A. Nutescu, Victor R. Gordeuk, Santosh L. Saraf, Jin Han

Research output: Contribution to journalArticlepeer-review


Background: Point-of-care (POC) International Normalized Ratio (INR) measurement provides efficient monitoring of warfarin therapy; however, its reliability may be affected in patients with anemia, such as those with sickle cell disease (SCD). Objectives: To evaluate the correlation of POC-INR to clinical laboratory INR (CL-INR) in SCD and use of a correction factor. Patient/Methods: In this retrospective study, the accuracy of POC-INR compared to CL-INR was evaluated in a cohort of patients with SCD and in a non-SCD Black cohort. Results: Despite the difference in anemia, the SCD cohort showed a similar percentage of in-range POC-INR values as observed in the non-SCD cohort (37% vs 42%). The SCD cohort was randomly divided to form discovery and validation cohorts. In the discovery cohort, 86% of POC-INRs were in range when the POC-INRs were ˂4.0, but only 24% were in range if POC-INRs were ≥4.0. A linear regression of CL-INR versus POC-INR for POC-INR values ≥4.0 yielded a coefficient of 0.72 (95% confidence interval, 0.69-0.75); Multiplying POC-INR by this correction factor, rounded to 0.7 for ease of use in clinical practice, improved the proportion of in-range POC-INR values ≥4.0 from 24% to 100% in the SCD discovery cohort and from 19% to 95% in the SCD validation cohort. Similar findings applied to analyses of the non-SCD cohort. Conclusions: POC-INR and CL-INR in patients with SCD are similar when POC-INR is <4.0, and the accuracy of POC-INR values ≥4.0 can be improved by applying an institution-specific correction factor.

Original languageEnglish
Article numbere12533
JournalResearch and Practice in Thrombosis and Haemostasis
Issue number4
StatePublished - May 2021
Externally publishedYes


Dive into the research topics of 'Evaluation of point-of-care International Normalized Ratio in sickle cell disease'. Together they form a unique fingerprint.

Cite this