Evaluation of ofloxacin in the treatment of uncomplicated gonorrhea

Barry L. Smith, Marinella C. Cummings, Jean M. Covino, Solomon Benes, Kenneth Draft, William M. Mccormack

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12 Scopus citations


In an open study, a single oral dose of 400 mg of ofloxacin was administered to 40 men and 20 women who required treatment for uncomplicated gonococcal infection. Thirty-six men and 13 women were evaluable. Ofloxacin eradicated 49 of 49 urethral or endocervical gonococcal infections and 1 of 1 pharyngeal infection. There were 55 pretreatment isolates of Neisseria gonorrhoeae available for antimicrobial susceptibility testing. Twenty-four (43.6%) produced penicillinase. Eighteen (32.7%) isolates that did not produce penicillinase had penicillin MICs ⩾ 1.0 µ g/mL. Twelve (21.8%) isolates had tetracycline MICs ⩾ 16 µg/mL. The geometric mean minimal inhibitory concentrations (range) for 55 pretreatment N. gonorrhoeae isolates were: ofloxacin, 0.014 (.0078–.03) µ g/mL; penicillin, 6.30 (.125–128) µ g/mL; and tetracycline 1.61 (.03–128) µ g/mL. There were few side effects. Ofloxacin appears to be an effective and safe oral therapy for the treatment of infections caused by N. gonorrhoeae including infections due to penicillin- and tetracycline-resistant strains.

Original languageEnglish
Pages (from-to)18-20
Number of pages3
JournalSexually Transmitted Diseases
Issue number1
StatePublished - 1991
Externally publishedYes


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