Evaluation of oestrogenicity and pregnancy interceptory efficacy of lapachol (2‐hydroxy‐3‐(3‐methyl‐2‐butenyl)‐1,4‐naphthoquinone) in the mouse

Vineeta Sareen, Sunita Jain, Anita Narula

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Lapachol, a naphthoquinone isolated from Tectona grandis was evaluated for its oestrogenicity and antinidational activity in the mouse and was found to possess a statistically significant (p < 0.001) uterotrophic effect after administration of the drug at a dose of 20 mg/kg body weight/day/mouse, intramuscularly. However, in comparison with conjugated oestrogen, the drug proved to be a relatively weak oestrogenic. Lapachol when administered at the same dose level exhibited interceptory activity at all stages of early pregnancy.

Original languageEnglish
Pages (from-to)139-141
Number of pages3
JournalPhytotherapy Research
Volume9
Issue number2
DOIs
StatePublished - Mar 1995
Externally publishedYes

Keywords

  • antifertility
  • lapachol
  • oestrogenicity
  • pregnancy interception

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