TY - JOUR
T1 - Evaluation of clinical, microscopic, and ultrastructural changes after treatment with a novel Q-switched Nd:YAG laser
AU - Berlin, Alexander L.
AU - Dudelzak, Jacob
AU - Hussain, Mussarrat
AU - Phelps, Robert
AU - Goldberg, David J.
N1 - Funding Information:
Disclosure: The study was supported, in part, by a grant from HOYA ConBio.
PY - 2008
Y1 - 2008
N2 - Background: The Q-switched Nd:YAG laser was among the first non-ablative lasers to be used. High-fluence photoacoustic Q-switched laser treatments were shown to produce results akin to those seen with some ablative lasers. Previous low-fluence, non-thermal, Q-switched Nd:YAG lasers produced almost no results. Objective: The purpose of this study was to evaluate a new combined photoacoustic/photothermal low-fluence Q-switched Nd:YAG laser in the treatment of facial photodamage. Methods: Ten individuals with photodamaged facial skin were enrolled in the study. Participants underwent six bi-weekly full-face treatments using a Q-switched Nd:YAG laser (RevLite, HOYA ConBio, Freemont, CA, USA) at 1064 nm, with an 8-mm spot size and fluence of 3.2 J/cm2. Clinical improvement was evaluated through blinded investigator assessment of photographs obtained before and 3 months after the last treatment. Pre-auricular biopsies, performed before and 3 months following the last treatment, were processed for light and electron microscopy and analyzed for evidence of treatment-related changes. Results: Eight individuals completed the study with no serious or long-term complications. Blinded evaluator assessment documented improvement in a variety of different aspects of photodamaged skin. Biopsy specimens revealed changes consistent with wound repair under light microscopy, while electron microscopy confirmed new collagen deposition. Conclusion: A novel combined photoacoustic/photothermal Q-switched Nd:YAG laser can be used for non-ablative photorejuvenation. In addition to clinical improvement, histological and ultrastructural changes consistent with new collagen deposition were noted.
AB - Background: The Q-switched Nd:YAG laser was among the first non-ablative lasers to be used. High-fluence photoacoustic Q-switched laser treatments were shown to produce results akin to those seen with some ablative lasers. Previous low-fluence, non-thermal, Q-switched Nd:YAG lasers produced almost no results. Objective: The purpose of this study was to evaluate a new combined photoacoustic/photothermal low-fluence Q-switched Nd:YAG laser in the treatment of facial photodamage. Methods: Ten individuals with photodamaged facial skin were enrolled in the study. Participants underwent six bi-weekly full-face treatments using a Q-switched Nd:YAG laser (RevLite, HOYA ConBio, Freemont, CA, USA) at 1064 nm, with an 8-mm spot size and fluence of 3.2 J/cm2. Clinical improvement was evaluated through blinded investigator assessment of photographs obtained before and 3 months after the last treatment. Pre-auricular biopsies, performed before and 3 months following the last treatment, were processed for light and electron microscopy and analyzed for evidence of treatment-related changes. Results: Eight individuals completed the study with no serious or long-term complications. Blinded evaluator assessment documented improvement in a variety of different aspects of photodamaged skin. Biopsy specimens revealed changes consistent with wound repair under light microscopy, while electron microscopy confirmed new collagen deposition. Conclusion: A novel combined photoacoustic/photothermal Q-switched Nd:YAG laser can be used for non-ablative photorejuvenation. In addition to clinical improvement, histological and ultrastructural changes consistent with new collagen deposition were noted.
KW - Lasers and light sources
KW - Photorejuvenation
UR - http://www.scopus.com/inward/record.url?scp=45849153825&partnerID=8YFLogxK
U2 - 10.1080/14764170802071165
DO - 10.1080/14764170802071165
M3 - Article
C2 - 18569259
AN - SCOPUS:45849153825
SN - 1476-4172
VL - 10
SP - 76
EP - 79
JO - Journal of Cosmetic and Laser Therapy
JF - Journal of Cosmetic and Laser Therapy
IS - 2
ER -