Evaluation of candidate genes for DYX1 and DYX2 in families with dyslexia

Zoran Brkanac, Nicola H. Chapman, Mark M. Matsushita, Lani Chun, Kathleen Nielsen, Elizabeth Cochrane, Virginia W. Berninger, Ellen M. Wijsman, Wendy H. Raskind

Research output: Contribution to journalArticlepeer-review

79 Scopus citations

Abstract

Dyslexia is a common heterogeneous disorder with a significant genetic component. Multiple studies have replicated the evidence for linkage between variously defined phenotypes of dyslexia and chromosomal regions on 15q21 (DYX1) and 6p22.2 (DYX2). Based on association studies and the possibility for functional significance of several polymorphisms, candidate genes responsible for the observed linkage signal have been proposed - DYX1C1 for 15q21, and KIAA0319 and DCDC2 for 6p22.2. We investigated the evidence for contribution of these candidate genes to dyslexia in our sample of multigenerational families. Our previous quantitative linkage analyses in this dataset provided supportive evidence for linkage of dyslexia to the locus on chromosome 15, but not to the locus on chromosome 6. In the current study, we used probands from 191 families for a case control analysis, and proband-parent trios for family-based TDT analyses. The observation of weak evidence for transmission disequilibrium for one of the two studied polymorphisms in DYX1C1 suggests involvement of this gene in dyslexia in our dataset. We did not find evidence for the association of KIAA0319 or DCDC2 alleles to dyslexia in our sample. We observed a slight tendency for an intronic deletion in DCDC2 to be associated with worse performance on some quantitative measures of dyslexia in the probands in our sample, but not in their parents.

Original languageEnglish
Pages (from-to)556-560
Number of pages5
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume144
Issue number4
DOIs
StatePublished - 5 Jun 2007
Externally publishedYes

Keywords

  • Candidate genes
  • DYX1
  • DYX2
  • Dyslexia
  • Genetic association

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