TY - JOUR
T1 - Evaluation of behavioral impulsivity and aggression tasks as endophenotypes for borderline personality disorder
AU - McCloskey, Michael S.
AU - New, Antonia S.
AU - Siever, Larry J.
AU - Goodman, Marianne
AU - Koenigsberg, Harold W.
AU - Flory, Janine D.
AU - Coccaro, Emil F.
N1 - Funding Information:
Funding for this study was provided by grant from the national institute of health (NIH), Veterans Administration (VA) and the borderline personality disorder research foundation (BPDRF). Neither the NIH, VA, nor the BPDRF had any further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the paper for publication.
Funding Information:
The authors would like to thank Bing Chen and Shauna Weinstein for their invaluable assistance with data management and analysis. Funding for this study was provided by the Borderline Personality Disorder Research Foundation (Siever, Coccaro), VA (MERIT award, New) and the NIH (RO1 MH63875, Siever).
PY - 2009/8
Y1 - 2009/8
N2 - Borderline personality disorder (BPD) is marked by aggression and impulsive, often self-destructive behavior. Despite the severe risks associated with BPD, relatively little is known about the disorder's etiology. Identification of genetic correlates (endophenotypes) of BPD would improve the prospects of targeted interventions for more homogeneous subsets of borderline patients characterized by specific genetic vulnerabilities. The current study evaluated behavioral measures of aggression and impulsivity as potential endophenotypes for BPD. Subjects with BPD (N = 127), a non cluster B personality disorder (OPD N = 122), or healthy volunteers (HV N = 112) completed self report and behavioral measures of aggression, motor impulsivity and cognitive impulsivity. Results showed that BPD subjects demonstrated more aggression and motor impulsivity than HV (but not OPD) subjects on behavioral tasks. In contrast, BPD subjects self-reported more impulsivity and aggression than either comparison group. Subsequent analyses showed that among BPD subjects behavioral aggression was associated with self-reported aggression, while behavioral and self-report impulsivity measures were more modestly associated. Overall, the results provide partial support for the use of behavioral measures of aggression and motor impulsivity as endophenotypes for BPD, with stronger support for behavioral aggression measures as an endophenotype for aggression within BPD samples.
AB - Borderline personality disorder (BPD) is marked by aggression and impulsive, often self-destructive behavior. Despite the severe risks associated with BPD, relatively little is known about the disorder's etiology. Identification of genetic correlates (endophenotypes) of BPD would improve the prospects of targeted interventions for more homogeneous subsets of borderline patients characterized by specific genetic vulnerabilities. The current study evaluated behavioral measures of aggression and impulsivity as potential endophenotypes for BPD. Subjects with BPD (N = 127), a non cluster B personality disorder (OPD N = 122), or healthy volunteers (HV N = 112) completed self report and behavioral measures of aggression, motor impulsivity and cognitive impulsivity. Results showed that BPD subjects demonstrated more aggression and motor impulsivity than HV (but not OPD) subjects on behavioral tasks. In contrast, BPD subjects self-reported more impulsivity and aggression than either comparison group. Subsequent analyses showed that among BPD subjects behavioral aggression was associated with self-reported aggression, while behavioral and self-report impulsivity measures were more modestly associated. Overall, the results provide partial support for the use of behavioral measures of aggression and motor impulsivity as endophenotypes for BPD, with stronger support for behavioral aggression measures as an endophenotype for aggression within BPD samples.
KW - Aggression
KW - Borderline personality disorder
KW - Endophenotype
KW - Impulsivity
UR - http://www.scopus.com/inward/record.url?scp=67650723830&partnerID=8YFLogxK
U2 - 10.1016/j.jpsychires.2009.01.002
DO - 10.1016/j.jpsychires.2009.01.002
M3 - Article
C2 - 19232640
AN - SCOPUS:67650723830
SN - 0022-3956
VL - 43
SP - 1036
EP - 1048
JO - Journal of Psychiatric Research
JF - Journal of Psychiatric Research
IS - 12
ER -