Evaluation of a sequential 5-FU and hydroxyurea combination in advanced bowel cancer

A. K. Kao; F. M. Muggia; N. Dubin; W. A. Lerner; R. Stark; J. C. Wernz; J. L. Speyer; R. H. Blum

Evaluation of a sequential 5-FU and hydroxyurea combination in advanced bowel cancer

A. K. Kao, F. M. Muggia, N. Dubin, W. A. Lerner, R. Stark, J. C. Wernz, J. L. Speyer, R. H. Blum

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14 Scopus citations

Abstract

Twenty-nine patients (two with small bowel cancer and 27 with colorectal cancer) were treated with a sequential 5-FU-hydroxyurea combination following the suggestion of schedule-dependent synergism in experimental systems. No enhanced toxicity was observed, but the response rate was only 4%. Seven additional patients manifested ≥ 50% declines in CEA, but caution must be used in interpreting such changes as antitumor activity.

Original language	English
Pages (from-to)	1383-1385
Number of pages	3
Journal	Cancer Treatment Reports
Volume	68
Issue number	11
State	Published - 1984

Cite this

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title = "Evaluation of a sequential 5-FU and hydroxyurea combination in advanced bowel cancer",

abstract = "Twenty-nine patients (two with small bowel cancer and 27 with colorectal cancer) were treated with a sequential 5-FU-hydroxyurea combination following the suggestion of schedule-dependent synergism in experimental systems. No enhanced toxicity was observed, but the response rate was only 4%. Seven additional patients manifested ≥ 50% declines in CEA, but caution must be used in interpreting such changes as antitumor activity.",

author = "Kao, {A. K.} and Muggia, {F. M.} and N. Dubin and Lerner, {W. A.} and R. Stark and Wernz, {J. C.} and Speyer, {J. L.} and Blum, {R. H.}",

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AU - Kao, A. K.

AU - Muggia, F. M.

AU - Dubin, N.

AU - Lerner, W. A.

AU - Stark, R.

AU - Wernz, J. C.

AU - Speyer, J. L.

AU - Blum, R. H.

PY - 1984

Y1 - 1984

N2 - Twenty-nine patients (two with small bowel cancer and 27 with colorectal cancer) were treated with a sequential 5-FU-hydroxyurea combination following the suggestion of schedule-dependent synergism in experimental systems. No enhanced toxicity was observed, but the response rate was only 4%. Seven additional patients manifested ≥ 50% declines in CEA, but caution must be used in interpreting such changes as antitumor activity.

AB - Twenty-nine patients (two with small bowel cancer and 27 with colorectal cancer) were treated with a sequential 5-FU-hydroxyurea combination following the suggestion of schedule-dependent synergism in experimental systems. No enhanced toxicity was observed, but the response rate was only 4%. Seven additional patients manifested ≥ 50% declines in CEA, but caution must be used in interpreting such changes as antitumor activity.

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AN - SCOPUS:0021733916

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VL - 68

SP - 1383

EP - 1385

JO - Cancer Treatment Reports

JF - Cancer Treatment Reports

IS - 11

ER -

Evaluation of a sequential 5-FU and hydroxyurea combination in advanced bowel cancer

Abstract

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