Despite important clinical advances in prevention and treatment of atherosclerosis during the past 20 years, coronary artery disease remains the first cause of mortality in industrialized countries.1 Atherosclerosis affects medium-and large-diameter arteries and is characterized by a thickening of the arterial intima typically composed of a lipid core with an overlying fibrous cap. Angiography remains the gold standard for diagnosis and quantification of atherosclerotic plaques that result in flow-limiting arterial stenoses but offers only an indirect view of atherosclerosis burden.2 Positive remodeling of the arterial wall-a process in which the vessel dilates to limit the narrowing of the lumen in presence of atherosclerotic plaques-leads to a clear underestimation of the true extension of atherosclerosis disease with angiography.3

Original languageEnglish
Title of host publicationCardiac PET and PET/CT Imaging
PublisherSpringer New York
Number of pages13
ISBN (Print)9780387352756
StatePublished - 2007


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