Evaluating the Potential of T Cell Receptor Repertoires in Predicting the Prognosis of Resectable Non-Small Cell Lung Cancers

Zhengbo Song, Xiangbin Chen, Yi Shi, Rongfang Huang, Wenxian Wang, Kunshou Zhu, Shaofeng Lin, Minxian Wang, Geng Tian, Jialiang Yang, Gang Chen

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

For resectable cancer patients, a method that could precisely predict the risk of postoperative recurrence would be crucial for guiding adjuvant treatment. Since T cell receptor (TCR) repertoires had been shown to be closely related to the dynamics of cancers, here we enrolled a cohort of patients to evaluate the potential of TCR repertoires in predicting the prognosis of resectable non-small cell lung cancers. Specifically, TCRβ repertoires were analyzed in surgical tumor tissues and matched adjacent non-tumor tissues from 39 patients enrolled with resectable non-small cell lung cancer, through target enrichment and high-throughput sequencing. As a result, there are significant differences between the TCR repertories of tumor samples and those of matched adjacent non-tumor samples as evaluated by criteria like the number of clonotypes. In addition, TCR repertoires were significantly associated with a few clinical features, as well as somatic mutations. Finally, certain TCRβ variable-joining (V-J) pairings were featured to build a logistic regression model in predicting postoperative recurrence of resectable non-small cell lung cancers with a testing area under the receiver operating characteristic curve (AUC) of around 0.9. Thus, we hypothesize that TCR repertoires could be potentially used to predict prognosis after curative surgery for non-small cell lung cancer patients.

Original languageEnglish
Pages (from-to)73-83
Number of pages11
JournalMolecular Therapy Methods and Clinical Development
Volume18
DOIs
StatePublished - 11 Sep 2020
Externally publishedYes

Keywords

  • T cell receptor repertoires
  • bioinformatics
  • prognosis
  • recurrence
  • resectable lung cancer

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