TY - JOUR
T1 - Evaluating the central vein sign in paediatric-onset multiple sclerosis
T2 - A case series study
AU - Boccia, Vincenzo Daniele
AU - Lapucci, Caterina
AU - Cellerino, Maria
AU - Tazza, Francesco
AU - Rossi, Andrea
AU - Schiavi, Simona
AU - Mancardi, Maria Margherita
AU - Inglese, Matilde
N1 - Funding Information:
The author(s) declared the following potential conflicts of interest with respect to the research, authorship and/or publication of this article: C.L. received travel grants from Novartis, Roche and Merck. M.C. received consulting fees from Novartis, Genzyme, Teva and Zambon. M.I. received research grants from NIH, DOD, NMSS, FISM and Roche; and received consulting fees from Novartis, Roche, Merck, Sanofi-Genzyme, Janssen and Admirall. The other authors declare no conflicting interests.
Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: This work was developed within the framework of the DINOGMI Department of Excellence of MIUR 2018–2022 (legge 232 del 2016). This work was supported by grants from Italian Ministry of Health (Rete delle Neuroscienze e della Neuroriabilitazione).
Publisher Copyright:
© The Author(s), 2022.
PY - 2023/3
Y1 - 2023/3
N2 - The central vein sign (CVS) has been proposed as a biomarker of multiple sclerosis (MS). In adult-onset MS (AOMS), 40%-threshold of CVS positive (+) lesions demonstrated high accuracy for MS diagnosis. However, CVS+ lesions’ performance has not been characterized in paediatric-onset (POMS) yet. We compared the CVS contribution to MS diagnosis in 10 POMS and 12 disease-duration-matched AOMS patients. Three POMS patients did not meet the 40%-threshold, while all AOMS patients were correctly diagnosed as having MS. The high proportion of periventricular confluent lesions, excluded from the CVS assessment, seemed to impair CVS sensitivity in POMS diagnosis.
AB - The central vein sign (CVS) has been proposed as a biomarker of multiple sclerosis (MS). In adult-onset MS (AOMS), 40%-threshold of CVS positive (+) lesions demonstrated high accuracy for MS diagnosis. However, CVS+ lesions’ performance has not been characterized in paediatric-onset (POMS) yet. We compared the CVS contribution to MS diagnosis in 10 POMS and 12 disease-duration-matched AOMS patients. Three POMS patients did not meet the 40%-threshold, while all AOMS patients were correctly diagnosed as having MS. The high proportion of periventricular confluent lesions, excluded from the CVS assessment, seemed to impair CVS sensitivity in POMS diagnosis.
KW - MRI
KW - Paediatric-onset multiple sclerosis
KW - SWI
KW - central vein sign
KW - gradient echo plural contrast imaging
KW - relapsing remitting multiple sclerosis
UR - http://www.scopus.com/inward/record.url?scp=85144180641&partnerID=8YFLogxK
U2 - 10.1177/13524585221142319
DO - 10.1177/13524585221142319
M3 - Article
C2 - 36514274
AN - SCOPUS:85144180641
SN - 1352-4585
VL - 29
SP - 475
EP - 478
JO - Multiple Sclerosis Journal
JF - Multiple Sclerosis Journal
IS - 3
ER -